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Breast cancer combined prognostic model based on lactate metabolism genes

To investigate the impact of lactate metabolism genes, lactate metabolism-related genes (LMRG), and immune infiltrating cells on the prognosis of breast cancer. LMRG was identified via single-cell sequencing. Immune cell infiltration was obtained by the CIBERSORT method. The prognostic genes were ch...

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Autores principales: Lu, Na, Guan, Xiao, Bao, Wei, Fan, Zongyao, Zhang, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794285/
https://www.ncbi.nlm.nih.gov/pubmed/36595824
http://dx.doi.org/10.1097/MD.0000000000032485
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author Lu, Na
Guan, Xiao
Bao, Wei
Fan, Zongyao
Zhang, Jianping
author_facet Lu, Na
Guan, Xiao
Bao, Wei
Fan, Zongyao
Zhang, Jianping
author_sort Lu, Na
collection PubMed
description To investigate the impact of lactate metabolism genes, lactate metabolism-related genes (LMRG), and immune infiltrating cells on the prognosis of breast cancer. LMRG was identified via single-cell sequencing. Immune cell infiltration was obtained by the CIBERSORT method. The prognostic genes were chosen by cox regression and the least absolute selection operator approach. lactate metabolism-associated immune-infiltrating cells was determined by difference analysis. The GSE20685 dataset was used as an external validation cohort. The model’s prognostic usefulness was evaluated utilizing survival, immunological microenvironment, and drug sensitivity assessments. NDUFAF6 was most associated with breast cancer prognosis. We obtained a total of 450 LMRG. SUSD3, IL18, MAL2, and CDKN1C comprised the Model2. NK cell activation was most relevant to lactate metabolism. The combined prognostic model outperformed the individual model, with the area under the curve ranging from 0.7 to 0.8 in all three cohorts. The lactate metabolism-related combination model assisted in evaluating breast cancer prognosis, providing new insights for treatment, particularly immunotherapy.
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spelling pubmed-97942852022-12-28 Breast cancer combined prognostic model based on lactate metabolism genes Lu, Na Guan, Xiao Bao, Wei Fan, Zongyao Zhang, Jianping Medicine (Baltimore) 5700 To investigate the impact of lactate metabolism genes, lactate metabolism-related genes (LMRG), and immune infiltrating cells on the prognosis of breast cancer. LMRG was identified via single-cell sequencing. Immune cell infiltration was obtained by the CIBERSORT method. The prognostic genes were chosen by cox regression and the least absolute selection operator approach. lactate metabolism-associated immune-infiltrating cells was determined by difference analysis. The GSE20685 dataset was used as an external validation cohort. The model’s prognostic usefulness was evaluated utilizing survival, immunological microenvironment, and drug sensitivity assessments. NDUFAF6 was most associated with breast cancer prognosis. We obtained a total of 450 LMRG. SUSD3, IL18, MAL2, and CDKN1C comprised the Model2. NK cell activation was most relevant to lactate metabolism. The combined prognostic model outperformed the individual model, with the area under the curve ranging from 0.7 to 0.8 in all three cohorts. The lactate metabolism-related combination model assisted in evaluating breast cancer prognosis, providing new insights for treatment, particularly immunotherapy. Lippincott Williams & Wilkins 2022-12-23 /pmc/articles/PMC9794285/ /pubmed/36595824 http://dx.doi.org/10.1097/MD.0000000000032485 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5700
Lu, Na
Guan, Xiao
Bao, Wei
Fan, Zongyao
Zhang, Jianping
Breast cancer combined prognostic model based on lactate metabolism genes
title Breast cancer combined prognostic model based on lactate metabolism genes
title_full Breast cancer combined prognostic model based on lactate metabolism genes
title_fullStr Breast cancer combined prognostic model based on lactate metabolism genes
title_full_unstemmed Breast cancer combined prognostic model based on lactate metabolism genes
title_short Breast cancer combined prognostic model based on lactate metabolism genes
title_sort breast cancer combined prognostic model based on lactate metabolism genes
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794285/
https://www.ncbi.nlm.nih.gov/pubmed/36595824
http://dx.doi.org/10.1097/MD.0000000000032485
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