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Advanced stage cutaneous T-cell lymphoma treated with high-dose external beam radiation therapy: A case report

The treatment for advanced-stage or refractory cutaneous T-cell lymphoma (CTCL) is largely palliative. Due to the rarity of the disease, there are few randomized controlled trials and large-scale prospective studies. Therefore, the treatment of advanced-stage CTCL remains challenging. PATIENT CONCER...

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Autores principales: Youn, Sang Hee, Lee, Sun Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794289/
https://www.ncbi.nlm.nih.gov/pubmed/36595796
http://dx.doi.org/10.1097/MD.0000000000032239
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author Youn, Sang Hee
Lee, Sun Young
author_facet Youn, Sang Hee
Lee, Sun Young
author_sort Youn, Sang Hee
collection PubMed
description The treatment for advanced-stage or refractory cutaneous T-cell lymphoma (CTCL) is largely palliative. Due to the rarity of the disease, there are few randomized controlled trials and large-scale prospective studies. Therefore, the treatment of advanced-stage CTCL remains challenging. PATIENT CONCERNS AND DIAGNOSIS: A 64-years-old man who had received narrowband UVB phototherapy for several years presented with a generalized rash with widespread polycyclic erosions and painful ulcers on his hands and feet. We restaged him as stage III CTCL. INTERVENTIONS AND OUTCOMES: He was treated with high-dose radiation for curative purposes and 3-dimensional conformal radiation therapy to both hands and feet. At the 2-year follow-up after the end of radiotherapy, the irradiated skin had recovered to normal soft, smooth skin with localized fibrosis and hypopigmented skin. He reported an excellent quality of life, and his hands and feet were free to move. CONCLUSION: CTCL at an advanced stage could require dose escalation with local radiotherapy for curative purposes. High-dose 3-dementional conformal radiation therapy could be effective and has tolerable toxicities.
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spelling pubmed-97942892022-12-28 Advanced stage cutaneous T-cell lymphoma treated with high-dose external beam radiation therapy: A case report Youn, Sang Hee Lee, Sun Young Medicine (Baltimore) 5700 The treatment for advanced-stage or refractory cutaneous T-cell lymphoma (CTCL) is largely palliative. Due to the rarity of the disease, there are few randomized controlled trials and large-scale prospective studies. Therefore, the treatment of advanced-stage CTCL remains challenging. PATIENT CONCERNS AND DIAGNOSIS: A 64-years-old man who had received narrowband UVB phototherapy for several years presented with a generalized rash with widespread polycyclic erosions and painful ulcers on his hands and feet. We restaged him as stage III CTCL. INTERVENTIONS AND OUTCOMES: He was treated with high-dose radiation for curative purposes and 3-dimensional conformal radiation therapy to both hands and feet. At the 2-year follow-up after the end of radiotherapy, the irradiated skin had recovered to normal soft, smooth skin with localized fibrosis and hypopigmented skin. He reported an excellent quality of life, and his hands and feet were free to move. CONCLUSION: CTCL at an advanced stage could require dose escalation with local radiotherapy for curative purposes. High-dose 3-dementional conformal radiation therapy could be effective and has tolerable toxicities. Lippincott Williams & Wilkins 2022-12-23 /pmc/articles/PMC9794289/ /pubmed/36595796 http://dx.doi.org/10.1097/MD.0000000000032239 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5700
Youn, Sang Hee
Lee, Sun Young
Advanced stage cutaneous T-cell lymphoma treated with high-dose external beam radiation therapy: A case report
title Advanced stage cutaneous T-cell lymphoma treated with high-dose external beam radiation therapy: A case report
title_full Advanced stage cutaneous T-cell lymphoma treated with high-dose external beam radiation therapy: A case report
title_fullStr Advanced stage cutaneous T-cell lymphoma treated with high-dose external beam radiation therapy: A case report
title_full_unstemmed Advanced stage cutaneous T-cell lymphoma treated with high-dose external beam radiation therapy: A case report
title_short Advanced stage cutaneous T-cell lymphoma treated with high-dose external beam radiation therapy: A case report
title_sort advanced stage cutaneous t-cell lymphoma treated with high-dose external beam radiation therapy: a case report
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794289/
https://www.ncbi.nlm.nih.gov/pubmed/36595796
http://dx.doi.org/10.1097/MD.0000000000032239
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