Differential dosing of oxycodone in combination with propofol in diagnostic painless gastroscopy in elderly patients: A prospective randomized controlled trial

The aim of this study is to investigate the safety and efficacy of different doses of oxycodone in combination with propofol during painless gastroscopy. METHODS: 120 patients underwent painless gastroscopy under general anesthesia. According to the different doses of oxycodone, patients were divided into 4 groups, group A (oxycodone 0.025 mg/kg + propofol), group B (oxycodone 0.05 mg/kg + propofol) and group C (oxycodone 0.1 mg/kg + propofol), control group (propofol alone), with 30 cases in each group. The general characteristics of all patients were then evaluated. Mean arterial pressure (MAP), heart rate (HR) and peripheral capillary oxygen saturation (SpO2) were recorded at different time points, including the time before anesthesia (T0), failure of the lash reflex (T1), successful placement of the mirror (T2), removal of the mirror (T3) and waking up (T4). The intraoperative propofol dosage and the operative time of gastroscopy were recorded. The occurrence of adverse effects in the 4 groups was also compared. RESULTS: General characteristics, gastroscopy operative time and SpO2 did not differ significantly between the 4 groups (P > .05). However, group C had the lowest amount of propofol during gastroscopy (P < .05). At T1, groups A, B, and C had a faster HR than the control group (P < .05). At T2, groups A, B, and C had a lower MAP than the control group (P < .05). Groups B and C had fewer adverse effects than groups A and the control group (P < .05). Importantly, groups B and C had a shorter recovery time than groups A and the control group (P < .05), but no statistically significant differences were found between groups B and C. CONCLUSION: 0.05 mg/kg oxycodone in combination with propofol can be used safely and effectively for painless gastroscopy, with the advantages of a low propofol dose, maintenance of hemodynamic stability and few adverse effects.