Real-time transcription polymerase chain reaction cycle threshold values as criteria for utilization of incidental COVID-19 positive lung donors

Shortage of organ donors is an ongoing limiting factor in lung transplantation (LT). Despite increasing prevalence of asymptomatic COVID-19 infection, positive COVID-19 testing from a potential donor remains a contraindication at many LT centers. In this report, we present the outcomes of LT utilizi...

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Detalles Bibliográficos
Autores principales: Hwang, Josephine, Yuen, Alexander, Rhoades, Joshua, Barnes, Darina, Zakowski, Phillip, Megna, Dominick J., Catarino, Pedro, Zaffiri, Lorenzo, Rampolla, Reinaldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Society for Heart and Lung Transplantation. 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794393/
https://www.ncbi.nlm.nih.gov/pubmed/36624019
http://dx.doi.org/10.1016/j.healun.2022.12.016
Descripción
Sumario:Shortage of organ donors is an ongoing limiting factor in lung transplantation (LT). Despite increasing prevalence of asymptomatic COVID-19 infection, positive COVID-19 testing from a potential donor remains a contraindication at many LT centers. In this report, we present the outcomes of LT utilizing an algorithm based on donor clinical presentation, and COVID-19 real-time reverse transcription polymerase chain reaction (RT-PCR) with cycle threshold (Ct) values evaluation. The Ct value threshold for organ acceptance was >35. A total of 8 COVID-positive donors were included. No donor-to-recipient transmissions of COVID-19 were observed. Short-term outcomes were comparable to those reported in pre-COVID literature. Survival-to-date is 100% with median POD of 161 days. Our findings support the safety and efficacy of utilizing our algorithm including Ct value threshold for selection of donors with incidental COVID-19 positive testing.

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