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Relationship Between Fasting Blood Glucose Levels in Middle Age and Cognitive Function in Later Life: The Aichi Workers’ Cohort Study

BACKGROUND: There is limited evidence regarding the relationship between Diabetes mellitus (DM) in middle age and mild cognitive impairment after a follow-up. Therefore, we investigated the relationship between fasting blood glucose (FBG) levels in middle age and cognitive function assessed using th...

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Autores principales: Shimoda, Masako, Kaneko, Kayo, Nakagawa, Takeshi, Kawano, Naoko, Otsuka, Rei, Ota, Atsuhiko, Naito, Hisao, Matsunaga, Masaaki, Ichino, Naohiro, Yamada, Hiroya, Chiang, Chifa, Hirakawa, Yoshihisa, Tamakoshi, Koji, Aoyama, Atsuko, Yatsuya, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Epidemiological Association 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794446/
https://www.ncbi.nlm.nih.gov/pubmed/34024876
http://dx.doi.org/10.2188/jea.JE20210128
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author Shimoda, Masako
Kaneko, Kayo
Nakagawa, Takeshi
Kawano, Naoko
Otsuka, Rei
Ota, Atsuhiko
Naito, Hisao
Matsunaga, Masaaki
Ichino, Naohiro
Yamada, Hiroya
Chiang, Chifa
Hirakawa, Yoshihisa
Tamakoshi, Koji
Aoyama, Atsuko
Yatsuya, Hiroshi
author_facet Shimoda, Masako
Kaneko, Kayo
Nakagawa, Takeshi
Kawano, Naoko
Otsuka, Rei
Ota, Atsuhiko
Naito, Hisao
Matsunaga, Masaaki
Ichino, Naohiro
Yamada, Hiroya
Chiang, Chifa
Hirakawa, Yoshihisa
Tamakoshi, Koji
Aoyama, Atsuko
Yatsuya, Hiroshi
author_sort Shimoda, Masako
collection PubMed
description BACKGROUND: There is limited evidence regarding the relationship between Diabetes mellitus (DM) in middle age and mild cognitive impairment after a follow-up. Therefore, we investigated the relationship between fasting blood glucose (FBG) levels in middle age and cognitive function assessed using the Japanese version of the Montreal Cognitive Assessment (MoCA-J) in later life, following over 15 years of follow-up in the Aichi Workers’ Cohort Study in Japan. METHODS: Participants were 253 former local government employees aged 60–79 years in 2018 who participated in a baseline survey conducted in 2002. Using baseline FBG levels and self-reported history, participants were classified into the normal, impaired fasting glucose (IFG) and, and DM groups. Total MoCA-J score ranges from 0 to 30, and cognitive impairment was defined as MoCA-J score ≤25 in this study. A general linear model was used to estimate the mean MoCA-J scores in the FBG groups, adjusted for age, sex, educational year, smoking status, alcohol consumption, physical activity, body mass index, systolic blood pressure, total cholesterol, and estimated glomerular filtration rate. RESULTS: The mean MoCA-J score in the total population was 25.0, and the prevalence of MoCA-J score ≤25 was 49.0%. Multivariable-adjusted total MoCA-J scores were 25.2, 24.8, and 23.4 in the normal, IFG, and DM groups, respectively. The odds ratio of MoCA-J score ≤25 in the DM group was 3.29. CONCLUSION: FBG level in middle age was negatively associated with total MoCA-J scores assessed later in life, independent of confounding variables.
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spelling pubmed-97944462023-02-06 Relationship Between Fasting Blood Glucose Levels in Middle Age and Cognitive Function in Later Life: The Aichi Workers’ Cohort Study Shimoda, Masako Kaneko, Kayo Nakagawa, Takeshi Kawano, Naoko Otsuka, Rei Ota, Atsuhiko Naito, Hisao Matsunaga, Masaaki Ichino, Naohiro Yamada, Hiroya Chiang, Chifa Hirakawa, Yoshihisa Tamakoshi, Koji Aoyama, Atsuko Yatsuya, Hiroshi J Epidemiol Original Article BACKGROUND: There is limited evidence regarding the relationship between Diabetes mellitus (DM) in middle age and mild cognitive impairment after a follow-up. Therefore, we investigated the relationship between fasting blood glucose (FBG) levels in middle age and cognitive function assessed using the Japanese version of the Montreal Cognitive Assessment (MoCA-J) in later life, following over 15 years of follow-up in the Aichi Workers’ Cohort Study in Japan. METHODS: Participants were 253 former local government employees aged 60–79 years in 2018 who participated in a baseline survey conducted in 2002. Using baseline FBG levels and self-reported history, participants were classified into the normal, impaired fasting glucose (IFG) and, and DM groups. Total MoCA-J score ranges from 0 to 30, and cognitive impairment was defined as MoCA-J score ≤25 in this study. A general linear model was used to estimate the mean MoCA-J scores in the FBG groups, adjusted for age, sex, educational year, smoking status, alcohol consumption, physical activity, body mass index, systolic blood pressure, total cholesterol, and estimated glomerular filtration rate. RESULTS: The mean MoCA-J score in the total population was 25.0, and the prevalence of MoCA-J score ≤25 was 49.0%. Multivariable-adjusted total MoCA-J scores were 25.2, 24.8, and 23.4 in the normal, IFG, and DM groups, respectively. The odds ratio of MoCA-J score ≤25 in the DM group was 3.29. CONCLUSION: FBG level in middle age was negatively associated with total MoCA-J scores assessed later in life, independent of confounding variables. Japan Epidemiological Association 2023-02-05 /pmc/articles/PMC9794446/ /pubmed/34024876 http://dx.doi.org/10.2188/jea.JE20210128 Text en © 2021 Masako Shimoda et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Shimoda, Masako
Kaneko, Kayo
Nakagawa, Takeshi
Kawano, Naoko
Otsuka, Rei
Ota, Atsuhiko
Naito, Hisao
Matsunaga, Masaaki
Ichino, Naohiro
Yamada, Hiroya
Chiang, Chifa
Hirakawa, Yoshihisa
Tamakoshi, Koji
Aoyama, Atsuko
Yatsuya, Hiroshi
Relationship Between Fasting Blood Glucose Levels in Middle Age and Cognitive Function in Later Life: The Aichi Workers’ Cohort Study
title Relationship Between Fasting Blood Glucose Levels in Middle Age and Cognitive Function in Later Life: The Aichi Workers’ Cohort Study
title_full Relationship Between Fasting Blood Glucose Levels in Middle Age and Cognitive Function in Later Life: The Aichi Workers’ Cohort Study
title_fullStr Relationship Between Fasting Blood Glucose Levels in Middle Age and Cognitive Function in Later Life: The Aichi Workers’ Cohort Study
title_full_unstemmed Relationship Between Fasting Blood Glucose Levels in Middle Age and Cognitive Function in Later Life: The Aichi Workers’ Cohort Study
title_short Relationship Between Fasting Blood Glucose Levels in Middle Age and Cognitive Function in Later Life: The Aichi Workers’ Cohort Study
title_sort relationship between fasting blood glucose levels in middle age and cognitive function in later life: the aichi workers’ cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794446/
https://www.ncbi.nlm.nih.gov/pubmed/34024876
http://dx.doi.org/10.2188/jea.JE20210128
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