Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury

Functional recovery after incomplete spinal cord injury depends on the effective rewiring of neuronal circuits. Here, we show that selective chemogenetic activation of either corticospinal projection neurons or intraspinal relay neurons alone led to anatomically restricted plasticity and little func...

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Autores principales: Van Steenbergen, Valérie, Burattini, Laura, Trumpp, Michelle, Fourneau, Julie, Aljović, Almir, Chahin, Maryam, Oh, Hanseul, D’Ambra, Marta, Bareyre, Florence M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794600/
https://www.ncbi.nlm.nih.gov/pubmed/36571760
http://dx.doi.org/10.1084/jem.20220615
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author Van Steenbergen, Valérie
Burattini, Laura
Trumpp, Michelle
Fourneau, Julie
Aljović, Almir
Chahin, Maryam
Oh, Hanseul
D’Ambra, Marta
Bareyre, Florence M.
author_facet Van Steenbergen, Valérie
Burattini, Laura
Trumpp, Michelle
Fourneau, Julie
Aljović, Almir
Chahin, Maryam
Oh, Hanseul
D’Ambra, Marta
Bareyre, Florence M.
author_sort Van Steenbergen, Valérie
collection PubMed
description Functional recovery after incomplete spinal cord injury depends on the effective rewiring of neuronal circuits. Here, we show that selective chemogenetic activation of either corticospinal projection neurons or intraspinal relay neurons alone led to anatomically restricted plasticity and little functional recovery. In contrast, coordinated stimulation of both supraspinal centers and spinal relay stations resulted in marked and circuit-specific enhancement of neuronal rewiring, shortened EMG latencies, and improved locomotor recovery.
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spelling pubmed-97946002023-06-26 Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury Van Steenbergen, Valérie Burattini, Laura Trumpp, Michelle Fourneau, Julie Aljović, Almir Chahin, Maryam Oh, Hanseul D’Ambra, Marta Bareyre, Florence M. J Exp Med Article Functional recovery after incomplete spinal cord injury depends on the effective rewiring of neuronal circuits. Here, we show that selective chemogenetic activation of either corticospinal projection neurons or intraspinal relay neurons alone led to anatomically restricted plasticity and little functional recovery. In contrast, coordinated stimulation of both supraspinal centers and spinal relay stations resulted in marked and circuit-specific enhancement of neuronal rewiring, shortened EMG latencies, and improved locomotor recovery. Rockefeller University Press 2022-12-26 /pmc/articles/PMC9794600/ /pubmed/36571760 http://dx.doi.org/10.1084/jem.20220615 Text en © 2022 Van Steenbergen et al. https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Van Steenbergen, Valérie
Burattini, Laura
Trumpp, Michelle
Fourneau, Julie
Aljović, Almir
Chahin, Maryam
Oh, Hanseul
D’Ambra, Marta
Bareyre, Florence M.
Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury
title Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury
title_full Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury
title_fullStr Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury
title_full_unstemmed Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury
title_short Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury
title_sort coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794600/
https://www.ncbi.nlm.nih.gov/pubmed/36571760
http://dx.doi.org/10.1084/jem.20220615
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