Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors

The inhibitory action of fifteen benzyloxy ortho/para-substituted chalcones (B1-B15) was evaluated against human monoamine oxidases (hMAOs). All the molecules inhibited hMAO-B isoform more potently than hMAO-A. Furthermore, the majority of the molecules showed strong inhibitory actions against hMAO-...

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Detalles Bibliográficos
Autores principales: Sudevan, Sachithra Thazhathuveedu, Oh, Jong Min, Abdelgawad, Mohamed A., Abourehab, Mohammed A. S., Rangarajan, T. M., Kumar, Sunil, Ahmad, Iqrar, Patel, Harun, Kim, Hoon, Mathew, Bijo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794710/
https://www.ncbi.nlm.nih.gov/pubmed/36575270
http://dx.doi.org/10.1038/s41598-022-26929-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794710/
https://www.ncbi.nlm.nih.gov/pubmed/36575270
http://dx.doi.org/10.1038/s41598-022-26929-x

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