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Expression of TRX1 optimizes the antitumor functions of human CAR T cells and confers resistance to a pro-oxidative tumor microenvironment

Use of chimeric antigen receptor (CAR) T cells to treat B cell lymphoma and leukemia has been remarkably successful. Unfortunately, the therapeutic efficacy of CAR T cells against solid tumors is very limited, with immunosuppression by the pro-oxidative tumor microenvironment (TME) a major contribut...

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Detalles Bibliográficos
Autores principales:	Balta, Emre, Janzen, Nina, Kirchgessner, Henning, Toufaki, Vasiliki, Orlik, Christian, Liang, Jie, Lairikyengbam, Divya, Abken, Hinrich, Niesler, Beate, Müller-Decker, Karin, Ruppert, Thomas, Samstag, Yvonne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794734/ https://www.ncbi.nlm.nih.gov/pubmed/36591284 http://dx.doi.org/10.3389/fimmu.2022.1063313

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