Prediction of designer-recombinases for DNA editing with generative deep learning

Site-specific tyrosine-type recombinases are effective tools for genome engineering, with the first engineered variants having demonstrated therapeutic potential. So far, adaptation to new DNA target site selectivity of designer-recombinases has been achieved mostly through iterative cycles of direc...

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Detalles Bibliográficos
Autores principales: Schmitt, Lukas Theo, Paszkowski-Rogacz, Maciej, Jug, Florian, Buchholz, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794738/
https://www.ncbi.nlm.nih.gov/pubmed/36575171
http://dx.doi.org/10.1038/s41467-022-35614-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794738/
https://www.ncbi.nlm.nih.gov/pubmed/36575171
http://dx.doi.org/10.1038/s41467-022-35614-6

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