The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1

The chromodomain helicase DNA-binding protein CHD8 is the most frequently mutated gene in autism spectrum disorder. Despite its prominent disease involvement, little is known about its molecular function in the human brain. CHD8 is a chromatin regulator which binds to the promoters of actively trans...

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Detalles Bibliográficos
Autores principales: Haddad Derafshi, Bahareh, Danko, Tamas, Chanda, Soham, Batista, Pedro J., Litzenburger, Ulrike, Lee, Qian Yi, Ng, Yi Han, Sebin, Anu, Chang, Howard Y., Südhof, Thomas C., Wernig, Marius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794786/
https://www.ncbi.nlm.nih.gov/pubmed/36575212
http://dx.doi.org/10.1038/s41598-022-23614-x

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