Loss of KDM5B ameliorates pathological cardiac fibrosis and dysfunction by epigenetically enhancing ATF3 expression

Excessive cardiac fibrosis is central to adverse cardiac remodeling and dysfunction leading to heart failure in many cardiac diseases. Histone methylation plays a crucial role in various pathophysiological events. However, the role of histone methylation modification enzymes in pathological cardiac...

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Detalles Bibliográficos
Autores principales: Wang, Bo, Tan, Yong, Zhang, Yunkai, Zhang, Sheng, Duan, Xuewen, Jiang, Yuyu, Li, Tong, Zhou, Qingqing, Liu, Xingguang, Zhan, Zhenzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794816/
https://www.ncbi.nlm.nih.gov/pubmed/36481938
http://dx.doi.org/10.1038/s12276-022-00904-y

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