Disrupted Ca(2+) homeostasis and immunodeficiency in patients with functional IP(3) receptor subtype 3 defects

Calcium signaling is essential for lymphocyte activation, with genetic disruptions of store-operated calcium (Ca(2+)) entry resulting in severe immunodeficiency. The inositol 1,4,5-trisphosphate receptor (IP(3)R), a homo- or heterotetramer of the IP(3)R1-3 isoforms, amplifies lymphocyte signaling by...

Descripción completa

Detalles Bibliográficos
Autores principales: Neumann, Julika, Van Nieuwenhove, Erika, Terry, Lara E., Staels, Frederik, Knebel, Taylor R., Welkenhuyzen, Kirsten, Ahmadzadeh, Kourosh, Baker, Mariah R., Gerbaux, Margaux, Willemsen, Mathijs, Barber, John S., Serysheva, Irina I., De Waele, Liesbeth, Vermeulen, François, Schlenner, Susan, Meyts, Isabelle, Yule, David I., Bultynck, Geert, Schrijvers, Rik, Humblet-Baron, Stephanie, Liston, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794825/
https://www.ncbi.nlm.nih.gov/pubmed/36302985
http://dx.doi.org/10.1038/s41423-022-00928-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794825/
https://www.ncbi.nlm.nih.gov/pubmed/36302985
http://dx.doi.org/10.1038/s41423-022-00928-4

Ejemplares similares