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Prediction of short-term treatment outcome of nasopharyngeal carcinoma based on voxel incoherent motion imaging and arterial spin labeling quantitative parameters
PURPOSE: To evaluate the early response of chemoradiotherapy (CRT) in nasopharyngeal carcinoma (NPC) based on intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) and three-dimensional pseudo-continuous arterial spin labeling (3D pCASL). MATERIALS AND METHODS: Forty patients diagnosed...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794885/ https://www.ncbi.nlm.nih.gov/pubmed/36590328 http://dx.doi.org/10.1016/j.ejro.2022.100466 |
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author | Liao, Liping Liu, Teng Wei, Bo |
author_facet | Liao, Liping Liu, Teng Wei, Bo |
author_sort | Liao, Liping |
collection | PubMed |
description | PURPOSE: To evaluate the early response of chemoradiotherapy (CRT) in nasopharyngeal carcinoma (NPC) based on intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) and three-dimensional pseudo-continuous arterial spin labeling (3D pCASL). MATERIALS AND METHODS: Forty patients diagnosed with NPC were recruited and divided into complete remission (CR) and partial remission (PR) group after CRT. All patients underwent IVIM and ASL and the related parameters was obtained. These parameters include pure diffusion coefficient (D), pseudo-diffusion coefficient (D*), perfusion fraction (f), average blood flow ( BF(avg)), minimum blood flow (BF(min)), and maximum blood flow (BF(max)). Student’s t test was used to compare the difference in ASL and IVIM derived parameters between CR and PR. The Areas under curve (AUC) of the receiver operating characteristic (ROC) was used to analyze the diagnostic performance of each parameter of ASL and IVIM to the treatment outcome. RESULTS: the D value of IVIM in CR group was lower than that of the PR group ( P = 0.014),. Among the parameters of ASL, the BF(avg) and BF(max) of the CR group were higher than those of the PR group(p = 0.004,0.013), but the BF(min) had no statistical significance in the two groups(P = 0.54). AUC of D, BF(avg), and BF(max) is about 0.731, 0.753, and 0.724, respectively, all of their combined AUC diagnosis was 0.812. CONCLUSION: The early response of NPC after CRT can predict by IVIM’s diffusion parameters and ASL-related blood flow parameters. |
format | Online Article Text |
id | pubmed-9794885 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-97948852022-12-29 Prediction of short-term treatment outcome of nasopharyngeal carcinoma based on voxel incoherent motion imaging and arterial spin labeling quantitative parameters Liao, Liping Liu, Teng Wei, Bo Eur J Radiol Open Original Article PURPOSE: To evaluate the early response of chemoradiotherapy (CRT) in nasopharyngeal carcinoma (NPC) based on intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) and three-dimensional pseudo-continuous arterial spin labeling (3D pCASL). MATERIALS AND METHODS: Forty patients diagnosed with NPC were recruited and divided into complete remission (CR) and partial remission (PR) group after CRT. All patients underwent IVIM and ASL and the related parameters was obtained. These parameters include pure diffusion coefficient (D), pseudo-diffusion coefficient (D*), perfusion fraction (f), average blood flow ( BF(avg)), minimum blood flow (BF(min)), and maximum blood flow (BF(max)). Student’s t test was used to compare the difference in ASL and IVIM derived parameters between CR and PR. The Areas under curve (AUC) of the receiver operating characteristic (ROC) was used to analyze the diagnostic performance of each parameter of ASL and IVIM to the treatment outcome. RESULTS: the D value of IVIM in CR group was lower than that of the PR group ( P = 0.014),. Among the parameters of ASL, the BF(avg) and BF(max) of the CR group were higher than those of the PR group(p = 0.004,0.013), but the BF(min) had no statistical significance in the two groups(P = 0.54). AUC of D, BF(avg), and BF(max) is about 0.731, 0.753, and 0.724, respectively, all of their combined AUC diagnosis was 0.812. CONCLUSION: The early response of NPC after CRT can predict by IVIM’s diffusion parameters and ASL-related blood flow parameters. Elsevier 2022-12-19 /pmc/articles/PMC9794885/ /pubmed/36590328 http://dx.doi.org/10.1016/j.ejro.2022.100466 Text en © 2022 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Liao, Liping Liu, Teng Wei, Bo Prediction of short-term treatment outcome of nasopharyngeal carcinoma based on voxel incoherent motion imaging and arterial spin labeling quantitative parameters |
title | Prediction of short-term treatment outcome of nasopharyngeal carcinoma based on voxel incoherent motion imaging and arterial spin labeling quantitative parameters |
title_full | Prediction of short-term treatment outcome of nasopharyngeal carcinoma based on voxel incoherent motion imaging and arterial spin labeling quantitative parameters |
title_fullStr | Prediction of short-term treatment outcome of nasopharyngeal carcinoma based on voxel incoherent motion imaging and arterial spin labeling quantitative parameters |
title_full_unstemmed | Prediction of short-term treatment outcome of nasopharyngeal carcinoma based on voxel incoherent motion imaging and arterial spin labeling quantitative parameters |
title_short | Prediction of short-term treatment outcome of nasopharyngeal carcinoma based on voxel incoherent motion imaging and arterial spin labeling quantitative parameters |
title_sort | prediction of short-term treatment outcome of nasopharyngeal carcinoma based on voxel incoherent motion imaging and arterial spin labeling quantitative parameters |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794885/ https://www.ncbi.nlm.nih.gov/pubmed/36590328 http://dx.doi.org/10.1016/j.ejro.2022.100466 |
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