DNA adducts as link between in vitro and in vivo carcinogenicity – A case study with benzo[a]pyrene

To reduce the need for animal tests, in vitro assays are often used as alternative methods. To derive toxic doses for higher tier organisms from in vitro assay results, quantitative in vitro-in vivo extrapolation (qIVIVE) based on physiological-based toxicokinetic (PBTK) models is typically the pref...

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Detalles Bibliográficos
Autores principales: Gerhards, Martin, Böhme, Alexander, Schubert, Kristin, Kodritsch, Bernhard, Ulrich, Nadin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794893/
https://www.ncbi.nlm.nih.gov/pubmed/36590448
http://dx.doi.org/10.1016/j.crtox.2022.100097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794893/
https://www.ncbi.nlm.nih.gov/pubmed/36590448
http://dx.doi.org/10.1016/j.crtox.2022.100097

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