Cargando…

DNA adducts as link between in vitro and in vivo carcinogenicity – A case study with benzo[a]pyrene

To reduce the need for animal tests, in vitro assays are often used as alternative methods. To derive toxic doses for higher tier organisms from in vitro assay results, quantitative in vitro-in vivo extrapolation (qIVIVE) based on physiological-based toxicokinetic (PBTK) models is typically the pref...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gerhards, Martin, Böhme, Alexander, Schubert, Kristin, Kodritsch, Bernhard, Ulrich, Nadin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794893/ https://www.ncbi.nlm.nih.gov/pubmed/36590448 http://dx.doi.org/10.1016/j.crtox.2022.100097

Ejemplares similares

Formation and persistence of benzo(a)pyrene metabolite-DNA adducts.
por: Stowers, S J, et al.
Publicado: (1985)

Benzo(a)pyrene diolepoxide-DNA adducts detected by synchronous fluorescence spectrophotometry.
por: Vahakangas, K, et al.
Publicado: (1985)

Neutrophils amplify the formation of DNA adducts by benzo[a]pyrene in lung target cells.
por: Borm, P J, et al.
Publicado: (1997)

Modulation of benzo[a]pyrene–DNA adduct formation by CYP1 inducer and inhibitor
por: Shiizaki, Kazuhiro, et al.
Publicado: (2017)

Examination of adduct formation in vivo in the mouse between benzo(a)pyrene and DNA of skin and hemoglobin of red blood cells.
por: Shugart, L, et al.
Publicado: (1985)

Resveratrol inhibits benzo[a]pyrene–DNA adduct formation in human bronchial epithelial cells
por: Berge, G, et al.
Publicado: (2004)

Biomarkers for individual susceptibility to carcinogenic agents: excretion and carcinogenic risk of benzo[a]pyrene metabolites.
por: Likhachev, A J, et al.
Publicado: (1992)

The carcinogenicity of some 6-substituted benzo(a)pyrene derivatives in mice.
por: Dewhurst, F., et al.
Publicado: (1972)

Chlorophyll catalyse the photo-transformation of carcinogenic benzo[a]pyrene in water
por: Luo, Lijuan, et al.
Publicado: (2015)

Tumors and DNA adducts in mice exposed to benzo[a]pyrene and coal tars: implications for risk assessment.
por: Goldstein, L S, et al.
Publicado: (1998)

Punicalagin and Ellagic Acid Demonstrate Antimutagenic Activity and Inhibition of Benzo[a]pyrene Induced DNA Adducts
por: Zahin, Maryam, et al.
Publicado: (2014)

Identification of Stable Benzo[a]pyrene-7,8-dione-DNA Adducts in Human Lung Cells
por: Huang, Meng, et al.
Publicado: (2013)

Prenatal Exposure to Polycyclic Aromatic Hydrocarbons, Benzo[a]pyrene–DNA Adducts, and Genomic DNA Methylation in Cord Blood
por: Herbstman, Julie B., et al.
Publicado: (2012)

Food borne bacterial models for detection of benzo[a]pyrene‐DNA adducts formation using RAPD‐PCR
por: Lanzone, Valentina, et al.
Publicado: (2016)

Protective Effects of Myricetin on Benzo[a]pyrene-Induced 8-Hydroxy-2′-Deoxyguanosine and BPDE-DNA Adduct
por: Jee, Seung-Cheol, et al.
Publicado: (2020)

Titanium Dioxide Nanoparticles As Guardian against Environmental Carcinogen Benzo[alpha]Pyrene
por: Dhasmana, Anupam, et al.
Publicado: (2014)

DNA Polymerase Eta Participates in the Mutagenic Bypass of Adducts Induced by Benzo[a]pyrene Diol Epoxide in Mammalian Cells
por: Klarer, Alden C., et al.
Publicado: (2012)

Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ
por: Jha, Vikash, et al.
Publicado: (2016)

Effect of Benzo[a]pyrene-DNA Adduct in Cord Blood on the Neurodevelopment of 12-Month-Old Infants in Qingdao City
por: Zhang, Yong, et al.
Publicado: (2019)

Enhanced DNA adduct formation by benzo[a]pyrene in human liver cells lacking cytochrome P450 oxidoreductase
por: Reed, Lindsay, et al.
Publicado: (2020)

Carcinogenicity of airborne fine particulate benzo(a)pyrene: an appraisal of the evidence and the need for control.
por: Perera, F
Publicado: (1981)

Simultaneous Measurement of Benzo[a]pyrene-induced Pig-a and lacZ Mutations, Micronuclei and DNA Adducts in Muta™ Mouse
por: Lemieux, Christine L, et al.
Publicado: (2011)

Formation Mechanism of Benzo(a)pyrene: One of the Most Carcinogenic Polycyclic Aromatic Hydrocarbons (PAH)
por: Reizer, Edina, et al.
Publicado: (2019)

The Ability of Airborne Microalgae and Cyanobacteria to Survive and Transfer the Carcinogenic Benzo(a)pyrene in Coastal Regions
por: Wiśniewska, Kinga A., et al.
Publicado: (2023)

Detection of Benzo[a]pyrene Diol Epoxide Adducts to Histidine and Lysine in Serum Albumin In Vivo by High-Resolution-Tandem Mass Spectrometry
por: Zurita, Javier, et al.
Publicado: (2022)

Postlabeling methods for carcinogen-DNA adduct analysis.
por: Randerath, K, et al.
Publicado: (1985)

Benzo [Image: see text] pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice
por: Zuo, Jie, et al.
Publicado: (2014)

The intervention mechanism of folic acid for benzo(a)pyrene toxic effects in vitro and in vivo
por: Wang, Pengcheng, et al.
Publicado: (2019)

A Common Carcinogen Benzo[a]pyrene Causes Neuronal Death in Mouse via Microglial Activation
por: Dutta, Kallol, et al.
Publicado: (2010)

Inflammation-associated extracellular β-glucuronidase alters cellular responses to the chemical carcinogen benzo[a]pyrene
por: Shi, Q., et al.
Publicado: (2015)

Cadmium alters the formation of benzo[a]pyrene DNA adducts in the RPTEC/TERT1 human renal proximal tubule epithelial cell line
por: Simon, Bridget R., et al.
Publicado: (2014)

DNA adducts and carcinogenicity of nitro-polycyclic aromatic hydrocarbons.
por: Fu, P P, et al.
Publicado: (1994)

UVA Photoirradiation of Methylated Benzo[a]pyrene and Benzo[e]pyrene leading to Induction of Lipid Peroxidation
por: Sáenz, Diógenes Herreño, et al.
Publicado: (2007)

Regulation of Benzo[a]pyrene-Mediated DNA- and Glutathione-Adduct Formation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Human Lung Cells
por: Gelhaus, Stacy L., et al.
Publicado: (2010)

Inhibition of HIV-1 Reverse Transcriptase-Catalyzed Synthesis by Intercalated DNA Benzo[a]Pyrene 7,8-Dihydrodiol-9,10-Epoxide Adducts
por: Chary, Parvathi, et al.
Publicado: (2013)

Serum Level of Antibody against Benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA Adducts in People Dermally Exposed to PAHs
por: Borska, Lenka, et al.
Publicado: (2014)

Interaction of benzo[a]pyrene diol epoxide isomers with human serum albumin: Site specific characterisation of adducts and associated kinetics
por: Motwani, Hitesh V., et al.
Publicado: (2016)

Bacillus subtilis is a Potential Degrader of Pyrene and Benzo[a]pyrene
por: Hunter, Rochelle D., et al.
Publicado: (2005)

Predicting the in vivo developmental toxicity of benzo[a]pyrene (BaP) in rats by an in vitro–in silico approach
por: Wang, Danlei, et al.
Publicado: (2021)

DNA adducts and related biomarkers in populations exposed to environmental carcinogens
por: Perera, Frederica, et al.
Publicado: (1992)

Cannot write session to /tmp/vufind_sessions/sess_7it9jksq5h2ekci2t4kaljao6p