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Assessment of stromal SCD-induced drug resistance of PDAC using 3D-printed zPDX model chips

Lipid metabolism is extensively reprogrammed in pancreatic ductal adenocarcinoma (PDAC). Stearoyl-coenzyme A desaturase (SCD) is a critical lipid regulator that was unexplored in PDAC. Here, we characterized the existence of cancer-associated fibroblasts (CAFs) with high SCD expression, and revealed...

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Detalles Bibliográficos
Autores principales:	Wu, Chuntao, Hu, Beiyuan, Wang, Lei, Wu, Xia, Gu, Haitao, Dong, Hanguang, Yan, Jiuliang, Qi, Zihao, Zhang, Qi, Chen, Huan, Yu, Bo, Hu, Sheng, Qian, Yu, Dong, Shuang, Li, Qiang, Wang, Xu, Long, Jiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794976/ https://www.ncbi.nlm.nih.gov/pubmed/36590169 http://dx.doi.org/10.1016/j.isci.2022.105723

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