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Evidence of somatic hypermutation in the antigen binding sites of patients with CLL harboring IGHV genes with 100% germline identity
Classification of patients with chronic lymphocytic leukemia (CLL) based on the somatic hypermutation (SHM) status of the clonotypic immunoglobulin heavy variable (IGHV) gene has established predictive and prognostic relevance. The SHM status is assessed based on the number of mutations within the I...
Autores principales: | Sofou, Electra, Zaragoza-Infante, Laura, Pechlivanis, Nikolaos, Karakatsoulis, Georgios, Notopoulou, Sofia, Stavroyianni, Niki, Psomopoulos, Fotis, Georgiou, Elisavet, de Septenville, Anne Langlois, Davi, Frederic, Agathangelidis, Andreas, Chatzidimitriou, Anastasia, Stamatopoulos, Kostas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795043/ https://www.ncbi.nlm.nih.gov/pubmed/36591518 http://dx.doi.org/10.3389/fonc.2022.1079772 |
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