Evidence of somatic hypermutation in the antigen binding sites of patients with CLL harboring IGHV genes with 100% germline identity

Classification of patients with chronic lymphocytic leukemia (CLL) based on the somatic hypermutation (SHM) status of the clonotypic immunoglobulin heavy variable (IGHV) gene has established predictive and prognostic relevance. The SHM status is assessed based on the number of mutations within the I...

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Detalles Bibliográficos
Autores principales: Sofou, Electra, Zaragoza-Infante, Laura, Pechlivanis, Nikolaos, Karakatsoulis, Georgios, Notopoulou, Sofia, Stavroyianni, Niki, Psomopoulos, Fotis, Georgiou, Elisavet, de Septenville, Anne Langlois, Davi, Frederic, Agathangelidis, Andreas, Chatzidimitriou, Anastasia, Stamatopoulos, Kostas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795043/
https://www.ncbi.nlm.nih.gov/pubmed/36591518
http://dx.doi.org/10.3389/fonc.2022.1079772

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