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Anti-N-methyl-D-aspartate Receptor Autoimmune Encephalitis: A Case Report

Anti-N-methyl-D-aspartate receptor encephalitis is a form of autoimmune encephalitis with acute or subacute neuropsychiatric symptoms. Despite this fact, due to a couple of factors, this condition remains insufficiently acknowledged and is an under-recognised clinical scenario. We describe a case of...

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Autores principales: Yadav, Bikash, Chaurasia, Dhiraj, Kharel, Abhiyan, Dhungana, Krishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Journal of the Nepal Medical Association 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795094/
https://www.ncbi.nlm.nih.gov/pubmed/36705182
http://dx.doi.org/10.31729/jnma.7307
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author Yadav, Bikash
Chaurasia, Dhiraj
Kharel, Abhiyan
Dhungana, Krishna
author_facet Yadav, Bikash
Chaurasia, Dhiraj
Kharel, Abhiyan
Dhungana, Krishna
author_sort Yadav, Bikash
collection PubMed
description Anti-N-methyl-D-aspartate receptor encephalitis is a form of autoimmune encephalitis with acute or subacute neuropsychiatric symptoms. Despite this fact, due to a couple of factors, this condition remains insufficiently acknowledged and is an under-recognised clinical scenario. We describe a case of a patient presenting with fever, headache and altered sensorium along with a history of disorientation, episodes of abnormal body movements and loss of consciousness in the later phase. She was initially thought to have Status epilepticus with tuberculous meningoencephalitis but her cognitive functions did not improve despite appropriate treatment. She displayed features away from the usual course of disease leading to suspicions of Autoimmune Encephalitis and Anti-N-methyl-D-aspartate receptor reports later confirmed the diagnosis. Methylprednisolone and Intravenous Immunoglobulin was started empirically and she was discharged in stable health with stabilised emotional and cognitive function with Azathioprine and Levetiracetam continued. Our findings suggested early diagnosis and prompt immunotherapy treatment beneficial for the outcome.
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spelling pubmed-97950942023-01-03 Anti-N-methyl-D-aspartate Receptor Autoimmune Encephalitis: A Case Report Yadav, Bikash Chaurasia, Dhiraj Kharel, Abhiyan Dhungana, Krishna JNMA J Nepal Med Assoc Case Report Anti-N-methyl-D-aspartate receptor encephalitis is a form of autoimmune encephalitis with acute or subacute neuropsychiatric symptoms. Despite this fact, due to a couple of factors, this condition remains insufficiently acknowledged and is an under-recognised clinical scenario. We describe a case of a patient presenting with fever, headache and altered sensorium along with a history of disorientation, episodes of abnormal body movements and loss of consciousness in the later phase. She was initially thought to have Status epilepticus with tuberculous meningoencephalitis but her cognitive functions did not improve despite appropriate treatment. She displayed features away from the usual course of disease leading to suspicions of Autoimmune Encephalitis and Anti-N-methyl-D-aspartate receptor reports later confirmed the diagnosis. Methylprednisolone and Intravenous Immunoglobulin was started empirically and she was discharged in stable health with stabilised emotional and cognitive function with Azathioprine and Levetiracetam continued. Our findings suggested early diagnosis and prompt immunotherapy treatment beneficial for the outcome. Journal of the Nepal Medical Association 2022-11 2022-11-30 /pmc/articles/PMC9795094/ /pubmed/36705182 http://dx.doi.org/10.31729/jnma.7307 Text en © The Author(s) 2018. https://creativecommons.org/licenses/by/4.0/This is an Open-Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Yadav, Bikash
Chaurasia, Dhiraj
Kharel, Abhiyan
Dhungana, Krishna
Anti-N-methyl-D-aspartate Receptor Autoimmune Encephalitis: A Case Report
title Anti-N-methyl-D-aspartate Receptor Autoimmune Encephalitis: A Case Report
title_full Anti-N-methyl-D-aspartate Receptor Autoimmune Encephalitis: A Case Report
title_fullStr Anti-N-methyl-D-aspartate Receptor Autoimmune Encephalitis: A Case Report
title_full_unstemmed Anti-N-methyl-D-aspartate Receptor Autoimmune Encephalitis: A Case Report
title_short Anti-N-methyl-D-aspartate Receptor Autoimmune Encephalitis: A Case Report
title_sort anti-n-methyl-d-aspartate receptor autoimmune encephalitis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795094/
https://www.ncbi.nlm.nih.gov/pubmed/36705182
http://dx.doi.org/10.31729/jnma.7307
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