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Exosomal long non-coding RNAs: novel molecules in gastrointestinal cancers’ progression and diagnosis

Gastrointestinal (GI) cancers arise in the GI tract and accessory organs, including the mouth, esophagus, stomach, liver, biliary tract, pancreas, small intestine, large intestine, and rectum. GI cancers are a major cause of cancer-related morbidity and mortality worldwide. Exosomes act as mediators...

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Autores principales: Roshani, Mohammad, Baniebrahimi, Ghazaleh, Mousavi, Mahboubeh, Zare, Noushid, Sadeghi, Reza, Salarinia, Reza, Sheida, Amirhossein, Molavizadeh, Danial, Sadeghi, Sara, Moammer, Farzaneh, Zolfaghari, Mohammad Reza, Mirzaei, Hamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795196/
https://www.ncbi.nlm.nih.gov/pubmed/36591473
http://dx.doi.org/10.3389/fonc.2022.1014949
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author Roshani, Mohammad
Baniebrahimi, Ghazaleh
Mousavi, Mahboubeh
Zare, Noushid
Sadeghi, Reza
Salarinia, Reza
Sheida, Amirhossein
Molavizadeh, Danial
Sadeghi, Sara
Moammer, Farzaneh
Zolfaghari, Mohammad Reza
Mirzaei, Hamed
author_facet Roshani, Mohammad
Baniebrahimi, Ghazaleh
Mousavi, Mahboubeh
Zare, Noushid
Sadeghi, Reza
Salarinia, Reza
Sheida, Amirhossein
Molavizadeh, Danial
Sadeghi, Sara
Moammer, Farzaneh
Zolfaghari, Mohammad Reza
Mirzaei, Hamed
author_sort Roshani, Mohammad
collection PubMed
description Gastrointestinal (GI) cancers arise in the GI tract and accessory organs, including the mouth, esophagus, stomach, liver, biliary tract, pancreas, small intestine, large intestine, and rectum. GI cancers are a major cause of cancer-related morbidity and mortality worldwide. Exosomes act as mediators of cell-to-cell communication, with pleiotropic activity in the regulation of homeostasis, and can be markers for diseases. Non-coding RNAs (ncRNAs), such as long non-coding RNAs (lncRNAs), can be transported by exosomes derived from tumor cells or non-tumor cells. They can be taken by recipient cells to alter their function or remodel the tumor microenvironment. Moreover, due to their uniquely low immunogenicity and excellent stability, exosomes can be used as natural carriers for therapeutic ncRNAs in vivo. Exosomal lncRNAs have a crucial role in regulating several cancer processes, including angiogenesis, proliferation, drug resistance, metastasis, and immunomodulation. Exosomal lncRNA levels frequently alter according to the onset and progression of cancer. Exosomal lncRNAs can therefore be employed as biomarkers for the diagnosis and prognosis of cancer. Exosomal lncRNAs can also monitor the patient’s response to chemotherapy while also serving as potential targets for cancer treatment. Here, we discuss the role of exosomal lncRNAs in the biology and possible future treatment of GI cancer.
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spelling pubmed-97951962022-12-29 Exosomal long non-coding RNAs: novel molecules in gastrointestinal cancers’ progression and diagnosis Roshani, Mohammad Baniebrahimi, Ghazaleh Mousavi, Mahboubeh Zare, Noushid Sadeghi, Reza Salarinia, Reza Sheida, Amirhossein Molavizadeh, Danial Sadeghi, Sara Moammer, Farzaneh Zolfaghari, Mohammad Reza Mirzaei, Hamed Front Oncol Oncology Gastrointestinal (GI) cancers arise in the GI tract and accessory organs, including the mouth, esophagus, stomach, liver, biliary tract, pancreas, small intestine, large intestine, and rectum. GI cancers are a major cause of cancer-related morbidity and mortality worldwide. Exosomes act as mediators of cell-to-cell communication, with pleiotropic activity in the regulation of homeostasis, and can be markers for diseases. Non-coding RNAs (ncRNAs), such as long non-coding RNAs (lncRNAs), can be transported by exosomes derived from tumor cells or non-tumor cells. They can be taken by recipient cells to alter their function or remodel the tumor microenvironment. Moreover, due to their uniquely low immunogenicity and excellent stability, exosomes can be used as natural carriers for therapeutic ncRNAs in vivo. Exosomal lncRNAs have a crucial role in regulating several cancer processes, including angiogenesis, proliferation, drug resistance, metastasis, and immunomodulation. Exosomal lncRNA levels frequently alter according to the onset and progression of cancer. Exosomal lncRNAs can therefore be employed as biomarkers for the diagnosis and prognosis of cancer. Exosomal lncRNAs can also monitor the patient’s response to chemotherapy while also serving as potential targets for cancer treatment. Here, we discuss the role of exosomal lncRNAs in the biology and possible future treatment of GI cancer. Frontiers Media S.A. 2022-12-14 /pmc/articles/PMC9795196/ /pubmed/36591473 http://dx.doi.org/10.3389/fonc.2022.1014949 Text en Copyright © 2022 Roshani, Baniebrahimi, Mousavi, Zare, Sadeghi, Salarinia, Sheida, Molavizadeh, Sadeghi, Moammer, Zolfaghari and Mirzaei https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Roshani, Mohammad
Baniebrahimi, Ghazaleh
Mousavi, Mahboubeh
Zare, Noushid
Sadeghi, Reza
Salarinia, Reza
Sheida, Amirhossein
Molavizadeh, Danial
Sadeghi, Sara
Moammer, Farzaneh
Zolfaghari, Mohammad Reza
Mirzaei, Hamed
Exosomal long non-coding RNAs: novel molecules in gastrointestinal cancers’ progression and diagnosis
title Exosomal long non-coding RNAs: novel molecules in gastrointestinal cancers’ progression and diagnosis
title_full Exosomal long non-coding RNAs: novel molecules in gastrointestinal cancers’ progression and diagnosis
title_fullStr Exosomal long non-coding RNAs: novel molecules in gastrointestinal cancers’ progression and diagnosis
title_full_unstemmed Exosomal long non-coding RNAs: novel molecules in gastrointestinal cancers’ progression and diagnosis
title_short Exosomal long non-coding RNAs: novel molecules in gastrointestinal cancers’ progression and diagnosis
title_sort exosomal long non-coding rnas: novel molecules in gastrointestinal cancers’ progression and diagnosis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795196/
https://www.ncbi.nlm.nih.gov/pubmed/36591473
http://dx.doi.org/10.3389/fonc.2022.1014949
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