Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report

We report the fourth described case of severe toxic rhabdomyolysis occurring in an 81-year-old woman caused by the concomitant administration of palbociclib taken at the usual dosage (125 mg per day) and simvastatin. To the best of our knowledge, this is the first reported case successfully treated...

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Autores principales: Poumeaud, François, Fontanier, Anna, Dion, Jérémie, Mathevet, Quentin, Cointault, Olivier, Uro-Coste, Emmanuelle, Marty, Céline, Dalenc, Florence, Girardie, Pierre, Rataboul, Anaïs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795206/
https://www.ncbi.nlm.nih.gov/pubmed/36591506
http://dx.doi.org/10.3389/fonc.2022.1026434
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author Poumeaud, François
Fontanier, Anna
Dion, Jérémie
Mathevet, Quentin
Cointault, Olivier
Uro-Coste, Emmanuelle
Marty, Céline
Dalenc, Florence
Girardie, Pierre
Rataboul, Anaïs
author_facet Poumeaud, François
Fontanier, Anna
Dion, Jérémie
Mathevet, Quentin
Cointault, Olivier
Uro-Coste, Emmanuelle
Marty, Céline
Dalenc, Florence
Girardie, Pierre
Rataboul, Anaïs
author_sort Poumeaud, François
collection PubMed
description We report the fourth described case of severe toxic rhabdomyolysis occurring in an 81-year-old woman caused by the concomitant administration of palbociclib taken at the usual dosage (125 mg per day) and simvastatin. To the best of our knowledge, this is the first reported case successfully treated by plasma exchanges, with complete functional recovery within two months. The severity of this case justifies further consideration of pharmacokinetic interactions between palbociclib or other CDK-4-6 inhibitors and statins, which potentially increase the risk of an adverse event.
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spelling pubmed-97952062022-12-29 Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report Poumeaud, François Fontanier, Anna Dion, Jérémie Mathevet, Quentin Cointault, Olivier Uro-Coste, Emmanuelle Marty, Céline Dalenc, Florence Girardie, Pierre Rataboul, Anaïs Front Oncol Oncology We report the fourth described case of severe toxic rhabdomyolysis occurring in an 81-year-old woman caused by the concomitant administration of palbociclib taken at the usual dosage (125 mg per day) and simvastatin. To the best of our knowledge, this is the first reported case successfully treated by plasma exchanges, with complete functional recovery within two months. The severity of this case justifies further consideration of pharmacokinetic interactions between palbociclib or other CDK-4-6 inhibitors and statins, which potentially increase the risk of an adverse event. Frontiers Media S.A. 2022-12-14 /pmc/articles/PMC9795206/ /pubmed/36591506 http://dx.doi.org/10.3389/fonc.2022.1026434 Text en Copyright © 2022 Poumeaud, Fontanier, Dion, Mathevet, Cointault, Uro-Coste, Marty, Dalenc, Girardie and Rataboul https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Poumeaud, François
Fontanier, Anna
Dion, Jérémie
Mathevet, Quentin
Cointault, Olivier
Uro-Coste, Emmanuelle
Marty, Céline
Dalenc, Florence
Girardie, Pierre
Rataboul, Anaïs
Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report
title Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report
title_full Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report
title_fullStr Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report
title_full_unstemmed Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report
title_short Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report
title_sort severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795206/
https://www.ncbi.nlm.nih.gov/pubmed/36591506
http://dx.doi.org/10.3389/fonc.2022.1026434
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