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Increasing helminth infection burden depauperates the diversity of the gut microbiota and alters its composition in mice
The gut microbiota constitutes a diverse community of organisms with pervasive effects on host homeostasis. The diversity and composition of the gut microbiota depend on both intrinsic (host genetics) and extrinsic (environmental) factors. Here, we investigated the reaction norms of fecal microbiota...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795360/ https://www.ncbi.nlm.nih.gov/pubmed/36589866 http://dx.doi.org/10.1016/j.crpvbd.2022.100082 |
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author | Guiver, Emmanuel Galan, Maxime Lippens, Cédric Bellenger, Jérôme Faivre, Bruno Sorci, Gabriele |
author_facet | Guiver, Emmanuel Galan, Maxime Lippens, Cédric Bellenger, Jérôme Faivre, Bruno Sorci, Gabriele |
author_sort | Guiver, Emmanuel |
collection | PubMed |
description | The gut microbiota constitutes a diverse community of organisms with pervasive effects on host homeostasis. The diversity and composition of the gut microbiota depend on both intrinsic (host genetics) and extrinsic (environmental) factors. Here, we investigated the reaction norms of fecal microbiota diversity and composition in three strains of mice infected with increasing doses of the gastrointestinal nematode Heligmosomoides polygyrus. We found that α-diversity (bacterial taxonomic unit richness) declined along the gradient of infective doses, and β-diversity (dissimilarity between the composition of the microbiota of uninfected and infected mice) increased as the infective dose increased. We did not find evidence for genotype by environment (host strain by infective dose) interactions, except when focusing on the relative abundance of the commonest bacterial families. A simulation approach also showed that significant genotype by environment interactions would have been hardly found even with much larger sample size. These results show that increasing parasite burden progressively depauperates microbiota diversity and contributes to rapidly change its composition, independently from the host genetic background. |
format | Online Article Text |
id | pubmed-9795360 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-97953602022-12-29 Increasing helminth infection burden depauperates the diversity of the gut microbiota and alters its composition in mice Guiver, Emmanuel Galan, Maxime Lippens, Cédric Bellenger, Jérôme Faivre, Bruno Sorci, Gabriele Curr Res Parasitol Vector Borne Dis Research Article The gut microbiota constitutes a diverse community of organisms with pervasive effects on host homeostasis. The diversity and composition of the gut microbiota depend on both intrinsic (host genetics) and extrinsic (environmental) factors. Here, we investigated the reaction norms of fecal microbiota diversity and composition in three strains of mice infected with increasing doses of the gastrointestinal nematode Heligmosomoides polygyrus. We found that α-diversity (bacterial taxonomic unit richness) declined along the gradient of infective doses, and β-diversity (dissimilarity between the composition of the microbiota of uninfected and infected mice) increased as the infective dose increased. We did not find evidence for genotype by environment (host strain by infective dose) interactions, except when focusing on the relative abundance of the commonest bacterial families. A simulation approach also showed that significant genotype by environment interactions would have been hardly found even with much larger sample size. These results show that increasing parasite burden progressively depauperates microbiota diversity and contributes to rapidly change its composition, independently from the host genetic background. Elsevier 2022-02-22 /pmc/articles/PMC9795360/ /pubmed/36589866 http://dx.doi.org/10.1016/j.crpvbd.2022.100082 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Guiver, Emmanuel Galan, Maxime Lippens, Cédric Bellenger, Jérôme Faivre, Bruno Sorci, Gabriele Increasing helminth infection burden depauperates the diversity of the gut microbiota and alters its composition in mice |
title | Increasing helminth infection burden depauperates the diversity of the gut microbiota and alters its composition in mice |
title_full | Increasing helminth infection burden depauperates the diversity of the gut microbiota and alters its composition in mice |
title_fullStr | Increasing helminth infection burden depauperates the diversity of the gut microbiota and alters its composition in mice |
title_full_unstemmed | Increasing helminth infection burden depauperates the diversity of the gut microbiota and alters its composition in mice |
title_short | Increasing helminth infection burden depauperates the diversity of the gut microbiota and alters its composition in mice |
title_sort | increasing helminth infection burden depauperates the diversity of the gut microbiota and alters its composition in mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795360/ https://www.ncbi.nlm.nih.gov/pubmed/36589866 http://dx.doi.org/10.1016/j.crpvbd.2022.100082 |
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