Targeting the overexpressed mitochondrial protein VDAC1 in a mouse model of Alzheimer’s disease protects against mitochondrial dysfunction and mitigates brain pathology

BACKGROUND: Alzheimer's disease (AD) exhibits mitochondrial dysfunctions associated with dysregulated metabolism, brain inflammation, synaptic loss, and neuronal cell death. As a key protein serving as the mitochondrial gatekeeper, the voltage-dependent anion channel-1 (VDAC1) that controls met...

Descripción completa

Detalles Bibliográficos
Autores principales: Verma, Ankit, Shteinfer-Kuzmine, Anna, Kamenetsky, Nikita, Pittala, Srinivas, Paul, Avijit, Nahon Crystal, Edna, Ouro, Alberto, Chalifa-Caspi, Vered, Pandey, Swaroop Kumar, Monsengo, Alon, Vardi, Noga, Knafo, Shira, Shoshan-Barmatz, Varda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795455/
https://www.ncbi.nlm.nih.gov/pubmed/36578022
http://dx.doi.org/10.1186/s40035-022-00329-7

Ejemplares similares

Ejemplares similares