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Silencing TLR4 using an ultrasound-targeted microbubble destruction-based shRNA system reduces ischemia-induced seizures in hyperglycemic rats

The toll-like receptor 4 (TLR4) pathway is involved in seizures. We investigated whether ultrasound-targeted microbubble destruction (UTMD)-mediated delivery of short hairpin RNA (shRNA) targeting the TLR4 gene (shRNA-TLR4) can reduce ischemia-induced seizures in rats with hyperglycemia. A total of...

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Detalles Bibliográficos
Autores principales:	Chen, Jia, Huang, Fami, Fang, Xiaobo, Li, Siying, Liang, Yanling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	De Gruyter 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795576/ https://www.ncbi.nlm.nih.gov/pubmed/36619717 http://dx.doi.org/10.1515/biol-2022-0526

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