Safety and microbiological activity of phage therapy in persons with cystic fibrosis colonized with Pseudomonas aeruginosa: study protocol for a phase 1b/2, multicenter, randomized, double-blind, placebo-controlled trial

BACKGROUND: Bacteriophages (phages) are a promising anti-infective option for human disease. Major gaps remain in understanding their potential utility. METHODS: This is a randomized, placebo-controlled, double-blind study of a single dose of intravenous phage in approximately 72 clinically stable a...

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Detalles Bibliográficos
Autores principales: Tamma, Pranita D., Souli, Maria, Billard, Michael, Campbell, Joseph, Conrad, Douglas, Ellison, Damon W., Evans, Beth, Evans, Scott R., Greenwood-Quaintance, Kerryl E., Filippov, Andrey A., Geres, Holly S., Hamasaki, Toshimitsu, Komarow, Lauren, Nikolich, Mikeljon P., Lodise, Thomas P., Nayak, Seema U., Norice-Tra, Carmelle, Patel, Robin, Pride, David, Russell, Janie, Van Tyne, Daria, Chambers, Henry F., FowlerJr, Vance G., Schooley, Robert T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795609/
https://www.ncbi.nlm.nih.gov/pubmed/36578069
http://dx.doi.org/10.1186/s13063-022-07047-5

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