Ancestral reconstruction reveals catalytic inactivation of activation-induced cytidine deaminase concomitant with cold water adaption in the Gadiformes bony fish

BACKGROUND: Antibody affinity maturation in vertebrates requires the enzyme activation-induced cytidine deaminase (AID) which initiates secondary antibody diversification by mutating the immunoglobulin loci. AID-driven antibody diversification is conserved across jawed vertebrates since bony and car...

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Detalles Bibliográficos
Autores principales: Ghorbani, Atefeh, Khataeipour, S. Javad, Solbakken, Monica H., Huebert, David N. G., Khoddami, Minasadat, Eslamloo, Khalil, Collins, Cassandra, Hori, Tiago, Jentoft, Sissel, Rise, Matthew L., Larijani, Mani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795746/
https://www.ncbi.nlm.nih.gov/pubmed/36575514
http://dx.doi.org/10.1186/s12915-022-01489-8

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