Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2

BACKGROUND: The COVID-19 pandemic is an infectious disease caused by SARS-CoV-2. The first step of SARS-CoV-2 infection is the recognition of angiotensin-converting enzyme 2 (ACE2) receptors by the receptor-binding domain (RBD) of the viral Spike (S) glycoprotein. Although the molecular and structur...

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Detalles Bibliográficos
Autores principales: Miluzio, Annarita, Cuomo, Alessandro, Cordiglieri, Chiara, Donnici, Lorena, Pesce, Elisa, Bombaci, Mauro, Conti, Matteo, Fasciani, Alessandra, Terracciano, Luigi, Manganaro, Lara, Toccafondi, Mirco, Scagliola, Alessandra, Oliveto, Stefania, Ricciardi, Sara, Grifantini, Renata, De Francesco, Raffaele, Abrignani, Sergio, Manfrini, Nicola, Biffo, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795807/
https://www.ncbi.nlm.nih.gov/pubmed/36584595
http://dx.doi.org/10.1016/j.ebiom.2022.104390

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