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Full‐field and multifocal electroretinogram in non‐diabetic controls and diabetics with and without retinopathy

OBJECTIVE: To compare retinal function assessed by full‐field electroretinography (ffERG) and multifocal electroretinography (mfERG) in diabetes without retinopathy, diabetes with moderate non‐proliferative diabetic retinopathy (NPDR) and in the absence of diabetes. METHODS: Scotopic and photopic ff...

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Autores principales: Ba‐Ali, Shakoor, Larsen, Michael, Andersen, Henrik Ullits, Lund‐Andersen, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795888/
https://www.ncbi.nlm.nih.gov/pubmed/35661609
http://dx.doi.org/10.1111/aos.15184
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author Ba‐Ali, Shakoor
Larsen, Michael
Andersen, Henrik Ullits
Lund‐Andersen, Henrik
author_facet Ba‐Ali, Shakoor
Larsen, Michael
Andersen, Henrik Ullits
Lund‐Andersen, Henrik
author_sort Ba‐Ali, Shakoor
collection PubMed
description OBJECTIVE: To compare retinal function assessed by full‐field electroretinography (ffERG) and multifocal electroretinography (mfERG) in diabetes without retinopathy, diabetes with moderate non‐proliferative diabetic retinopathy (NPDR) and in the absence of diabetes. METHODS: Scotopic and photopic ffERG and mfERG was made in non‐fasting volunteers, including 26 diabetic participants without retinopathy, 22 diabetic participants with moderate NPDR and 22 participants without diabetes using full International Society for Clinical Electrophysiology of Vision protocols. RESULTS: Of the ffERG responses, significant deviation (p ≤ 0.05, corrected for multiple sampling and other relevant confounders) from the non‐diabetic participants was seen in the diabetic participants only for the OP1‐OP3 oscillatory amplitudes and the OP2 implicit time. This finding was independent of whether retinopathy was present or not. For the mfERG, minor amplitude or implicit time deviations were found for a small number of rings (R2, R4 and R5). Receiver of operating characteristic analysis showed that the single most prominent abnormality of the ffERG in diabetes, regardless of whether retinopathy was present or not, was the OP2 implicit time (area under the curve ≥ 0.80). CONCLUSION: This bi‐modal study of electroretinographic characteristics found that the most prominent anomaly associated with diabetes was a prolongation of the implicit time of the OP2 of the scotopic ffERG, while the most prominent added effect of non‐proliferative diabetic retinopathy was a further prolongation of the OP2 implicit time. Although the variation in ERG characteristics is far too large for diagnostic purposes, the close association of the oscillatory potentials with the amacrine cells of the retina indicate that their function is particularly sensitive to diabetes.
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spelling pubmed-97958882022-12-28 Full‐field and multifocal electroretinogram in non‐diabetic controls and diabetics with and without retinopathy Ba‐Ali, Shakoor Larsen, Michael Andersen, Henrik Ullits Lund‐Andersen, Henrik Acta Ophthalmol Original Articles OBJECTIVE: To compare retinal function assessed by full‐field electroretinography (ffERG) and multifocal electroretinography (mfERG) in diabetes without retinopathy, diabetes with moderate non‐proliferative diabetic retinopathy (NPDR) and in the absence of diabetes. METHODS: Scotopic and photopic ffERG and mfERG was made in non‐fasting volunteers, including 26 diabetic participants without retinopathy, 22 diabetic participants with moderate NPDR and 22 participants without diabetes using full International Society for Clinical Electrophysiology of Vision protocols. RESULTS: Of the ffERG responses, significant deviation (p ≤ 0.05, corrected for multiple sampling and other relevant confounders) from the non‐diabetic participants was seen in the diabetic participants only for the OP1‐OP3 oscillatory amplitudes and the OP2 implicit time. This finding was independent of whether retinopathy was present or not. For the mfERG, minor amplitude or implicit time deviations were found for a small number of rings (R2, R4 and R5). Receiver of operating characteristic analysis showed that the single most prominent abnormality of the ffERG in diabetes, regardless of whether retinopathy was present or not, was the OP2 implicit time (area under the curve ≥ 0.80). CONCLUSION: This bi‐modal study of electroretinographic characteristics found that the most prominent anomaly associated with diabetes was a prolongation of the implicit time of the OP2 of the scotopic ffERG, while the most prominent added effect of non‐proliferative diabetic retinopathy was a further prolongation of the OP2 implicit time. Although the variation in ERG characteristics is far too large for diagnostic purposes, the close association of the oscillatory potentials with the amacrine cells of the retina indicate that their function is particularly sensitive to diabetes. John Wiley and Sons Inc. 2022-06-03 2022-12 /pmc/articles/PMC9795888/ /pubmed/35661609 http://dx.doi.org/10.1111/aos.15184 Text en © 2022 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Ba‐Ali, Shakoor
Larsen, Michael
Andersen, Henrik Ullits
Lund‐Andersen, Henrik
Full‐field and multifocal electroretinogram in non‐diabetic controls and diabetics with and without retinopathy
title Full‐field and multifocal electroretinogram in non‐diabetic controls and diabetics with and without retinopathy
title_full Full‐field and multifocal electroretinogram in non‐diabetic controls and diabetics with and without retinopathy
title_fullStr Full‐field and multifocal electroretinogram in non‐diabetic controls and diabetics with and without retinopathy
title_full_unstemmed Full‐field and multifocal electroretinogram in non‐diabetic controls and diabetics with and without retinopathy
title_short Full‐field and multifocal electroretinogram in non‐diabetic controls and diabetics with and without retinopathy
title_sort full‐field and multifocal electroretinogram in non‐diabetic controls and diabetics with and without retinopathy
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795888/
https://www.ncbi.nlm.nih.gov/pubmed/35661609
http://dx.doi.org/10.1111/aos.15184
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