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Raft platforms highly enriched in cholesterol: major scaffolds for IL‐6 signalling assembly with implications in inflammation and cancer
Interleukin‐6 (IL‐6) is a pleiotropic cytokine with complex and major roles in inflammation, which could be linked to the different ways IL‐6 signals at the plasma membrane. In this issue of FEBS Journal, Woo and co‐workers present evidence for the involvement of Eps15 homology domain‐containing pro...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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John Wiley and Sons Inc.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795985/ https://www.ncbi.nlm.nih.gov/pubmed/35727702 http://dx.doi.org/10.1111/febs.16547 |
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author | Mollinedo, Faustino |
author_facet | Mollinedo, Faustino |
author_sort | Mollinedo, Faustino |
collection | PubMed |
description | Interleukin‐6 (IL‐6) is a pleiotropic cytokine with complex and major roles in inflammation, which could be linked to the different ways IL‐6 signals at the plasma membrane. In this issue of FEBS Journal, Woo and co‐workers present evidence for the involvement of Eps15 homology domain‐containing protein 1 (EHD1)‐mediated lipid raft platforms, highly enriched in cholesterol, in the IL‐6 signalling pathway. Because of the strong connection between IL‐6, inflammation and cancer, one implication of this report is that agents or approaches targeting cholesterol‐rich raft platforms may assist the development of novel strategies to treat inflammatory and malignant diseases. Comment on: https://doi.org/10.1111/febs.16458 |
format | Online Article Text |
id | pubmed-9795985 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97959852022-12-28 Raft platforms highly enriched in cholesterol: major scaffolds for IL‐6 signalling assembly with implications in inflammation and cancer Mollinedo, Faustino FEBS J Commentaries Interleukin‐6 (IL‐6) is a pleiotropic cytokine with complex and major roles in inflammation, which could be linked to the different ways IL‐6 signals at the plasma membrane. In this issue of FEBS Journal, Woo and co‐workers present evidence for the involvement of Eps15 homology domain‐containing protein 1 (EHD1)‐mediated lipid raft platforms, highly enriched in cholesterol, in the IL‐6 signalling pathway. Because of the strong connection between IL‐6, inflammation and cancer, one implication of this report is that agents or approaches targeting cholesterol‐rich raft platforms may assist the development of novel strategies to treat inflammatory and malignant diseases. Comment on: https://doi.org/10.1111/febs.16458 John Wiley and Sons Inc. 2022-06-21 2022-10 /pmc/articles/PMC9795985/ /pubmed/35727702 http://dx.doi.org/10.1111/febs.16547 Text en © 2022 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Commentaries Mollinedo, Faustino Raft platforms highly enriched in cholesterol: major scaffolds for IL‐6 signalling assembly with implications in inflammation and cancer |
title | Raft platforms highly enriched in cholesterol: major scaffolds for IL‐6 signalling assembly with implications in inflammation and cancer |
title_full | Raft platforms highly enriched in cholesterol: major scaffolds for IL‐6 signalling assembly with implications in inflammation and cancer |
title_fullStr | Raft platforms highly enriched in cholesterol: major scaffolds for IL‐6 signalling assembly with implications in inflammation and cancer |
title_full_unstemmed | Raft platforms highly enriched in cholesterol: major scaffolds for IL‐6 signalling assembly with implications in inflammation and cancer |
title_short | Raft platforms highly enriched in cholesterol: major scaffolds for IL‐6 signalling assembly with implications in inflammation and cancer |
title_sort | raft platforms highly enriched in cholesterol: major scaffolds for il‐6 signalling assembly with implications in inflammation and cancer |
topic | Commentaries |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795985/ https://www.ncbi.nlm.nih.gov/pubmed/35727702 http://dx.doi.org/10.1111/febs.16547 |
work_keys_str_mv | AT mollinedofaustino raftplatformshighlyenrichedincholesterolmajorscaffoldsforil6signallingassemblywithimplicationsininflammationandcancer |