Adrenomedullin for biologic‐resistant Crohn's disease: A randomized, double‐blind, placebo‐controlled phase 2a clinical trial

BACKGROUND AND AIM: Adrenomedullin is a bioactive peptide with many pleiotropic effects, including mucosal healing and immunomodulation. Adrenomedullin has shown beneficial effects in rodent models of inflammatory bowel disease and, more importantly, in clinical trials including patients with ulcera...

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Detalles Bibliográficos
Autores principales: Kita, Toshihiro, Ashizuka, Shinya, Takeda, Teruyuki, Matsumoto, Takayuki, Ohmiya, Naoki, Nakase, Hiroshi, Motoya, Satoshi, Ohi, Hidehisa, Mitsuyama, Keiichi, Hisamatsu, Tadakazu, Kanmura, Shuji, Kato, Naoya, Ishihara, Shunji, Nakamura, Masanao, Moriyama, Tomohiko, Saruta, Masayuki, Nozaki, Ryoichi, Yamamoto, Shojiro, Inatsu, Haruhiko, Watanabe, Koji, Kitamura, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Clinical Trials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796011/
https://www.ncbi.nlm.nih.gov/pubmed/35840351
http://dx.doi.org/10.1111/jgh.15945

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