First‐in‐human phase 2 trial with mite allergoids coupled to mannan in subcutaneous and sublingual immunotherapy

BACKGROUND: Polymerized allergens conjugated to non‐oxidized mannan (PM‐allergoids) are novel vaccines targeting dendritic cells (DCs). Previous experimental data indicate that PM‐allergoids are readily taken up by DCs and induce Treg cells. This first‐in‐human study was aimed to evaluate safety and...

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Detalles Bibliográficos
Autores principales: Nieto, Antonio, Mazón, Ángel, Nieto, María, Ibáñez, Ethel, Jang, Dah‐Tay, Calaforra, Susana, Alba, Pilar, Pérez‐Francés, Carmen, Llusar, Ruth, Montoro, Javier, de Mateo, Antonio, Alamar, Remedios, El‐Qutob, David, Fernández, Javier, Moral, Luis, Toral, Teresa, Antón, Mónica, Andreu, Carmen, Ferrer, Ángel, Flores, Isabel‐María, Cerdá, Neus, del Pozo, Sandra, Caballero, Raquel, Subiza, José Luis, Casanovas, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796063/
https://www.ncbi.nlm.nih.gov/pubmed/35570712
http://dx.doi.org/10.1111/all.15374

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