Synthesis of Saturated N‐Heterocycles via a Catalytic Hydrogenation Cascade

Saturated N‐heterocycles are prominent motifs found in various natural products and pharmaceuticals. Despite the increasing interest in this class of compounds, the synthesis of saturated bicyclic azacycles requires tedious multi‐step syntheses. Herein, we present a one‐pot protocol for the synthesi...

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Detalles Bibliográficos
Autores principales: Wagener, Tobias, Pierau, Marco, Heusler, Arne, Glorius, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796080/
https://www.ncbi.nlm.nih.gov/pubmed/36589139
http://dx.doi.org/10.1002/adsc.202200601
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author Wagener, Tobias
Pierau, Marco
Heusler, Arne
Glorius, Frank
author_facet Wagener, Tobias
Pierau, Marco
Heusler, Arne
Glorius, Frank
author_sort Wagener, Tobias
collection PubMed
description Saturated N‐heterocycles are prominent motifs found in various natural products and pharmaceuticals. Despite the increasing interest in this class of compounds, the synthesis of saturated bicyclic azacycles requires tedious multi‐step syntheses. Herein, we present a one‐pot protocol for the synthesis of octahydroindoles, decahydroquinolines, and octahydroindolizines through a cascade reaction. [Image: see text]
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spelling pubmed-97960802022-12-28 Synthesis of Saturated N‐Heterocycles via a Catalytic Hydrogenation Cascade Wagener, Tobias Pierau, Marco Heusler, Arne Glorius, Frank Adv Synth Catal Communications Saturated N‐heterocycles are prominent motifs found in various natural products and pharmaceuticals. Despite the increasing interest in this class of compounds, the synthesis of saturated bicyclic azacycles requires tedious multi‐step syntheses. Herein, we present a one‐pot protocol for the synthesis of octahydroindoles, decahydroquinolines, and octahydroindolizines through a cascade reaction. [Image: see text] John Wiley and Sons Inc. 2022-06-23 2022-10-04 /pmc/articles/PMC9796080/ /pubmed/36589139 http://dx.doi.org/10.1002/adsc.202200601 Text en © 2022 The Authors. Advanced Synthesis & Catalysis published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Wagener, Tobias
Pierau, Marco
Heusler, Arne
Glorius, Frank
Synthesis of Saturated N‐Heterocycles via a Catalytic Hydrogenation Cascade
title Synthesis of Saturated N‐Heterocycles via a Catalytic Hydrogenation Cascade
title_full Synthesis of Saturated N‐Heterocycles via a Catalytic Hydrogenation Cascade
title_fullStr Synthesis of Saturated N‐Heterocycles via a Catalytic Hydrogenation Cascade
title_full_unstemmed Synthesis of Saturated N‐Heterocycles via a Catalytic Hydrogenation Cascade
title_short Synthesis of Saturated N‐Heterocycles via a Catalytic Hydrogenation Cascade
title_sort synthesis of saturated n‐heterocycles via a catalytic hydrogenation cascade
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796080/
https://www.ncbi.nlm.nih.gov/pubmed/36589139
http://dx.doi.org/10.1002/adsc.202200601
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