The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform‐Selective Inhibitors

Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a mitochondrial 1‐carbon metabolism enzyme, which is an attractive anticancer drug target as it is highly upregulated in cancer but is not expressed in healthy adult cells. Selective MTHFD2 inhibitors could therefore offer reduced side‐effects du...

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Detalles Bibliográficos
Autores principales: Scaletti, Emma R., Gustafsson Westergren, Robert, Andersson, Yasmin, Wiita, Elisee, Henriksson, Martin, Homan, Evert J., Jemth, Ann‐Sofie, Helleday, Thomas, Stenmark, Pål
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796130/
https://www.ncbi.nlm.nih.gov/pubmed/35712863
http://dx.doi.org/10.1002/cmdc.202200274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796130/
https://www.ncbi.nlm.nih.gov/pubmed/35712863
http://dx.doi.org/10.1002/cmdc.202200274

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