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A new dexpanthenol‐containing liquid cleanser for atopic‐prone skin: Results from two prospective clinical studies evaluating cutaneous tolerability, moisturization potential, and effects on barrier function

BACKGROUND: Gentle cleansing of the skin without further compromising its barrier function and moisture content and being simultaneously devoid of adverse effects on the skin microbiome are important features of body cleansers for atopic‐prone skin sufferers. For this population, a new dexpanthenol‐...

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Autores principales: Peltier, Erwan, Trapp, Sonja, de Salvo, Raffaella, Sun, Connie, Brandt, Marianne, Laing, Sabrina, Hennighausen, Natascha, Barrionuevo‐Gonzalez, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796422/
https://www.ncbi.nlm.nih.gov/pubmed/35866315
http://dx.doi.org/10.1111/jocd.15252
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author Peltier, Erwan
Trapp, Sonja
de Salvo, Raffaella
Sun, Connie
Brandt, Marianne
Laing, Sabrina
Hennighausen, Natascha
Barrionuevo‐Gonzalez, Ana
author_facet Peltier, Erwan
Trapp, Sonja
de Salvo, Raffaella
Sun, Connie
Brandt, Marianne
Laing, Sabrina
Hennighausen, Natascha
Barrionuevo‐Gonzalez, Ana
author_sort Peltier, Erwan
collection PubMed
description BACKGROUND: Gentle cleansing of the skin without further compromising its barrier function and moisture content and being simultaneously devoid of adverse effects on the skin microbiome are important features of body cleansers for atopic‐prone skin sufferers. For this population, a new dexpanthenol‐containing liquid cleanser (DCLC) was developed. METHODS: Two prospective 4‐week studies have been conducted. Study 1 investigated the effect of once‐daily DCLC on stratum corneum (SC) hydration, transepidermal water loss (TEWL), skin pH, and skin microbiome (all on the volar forearm) in adult subjects with dry skin (N = 44). Study 2 explored the cutaneous tolerability of DCLC and its effect on the microbiome biodiversity of the volar forearm skin in infants/children with atopic‐prone skin (N = 33, aged 6 months to 6 years). In the latter study, DCLC was applied 2–3 days/week in combination with an emollient applied at least twice daily. RESULTS: In Study 1, on Day 29, the mean change in skin surface capacitance from baseline was significantly greater in the forearm test area treated with DCLC than in the contralateral test area (control) treated with water only (5.16 vs. 3.65 a.u.; p = 0.011), suggesting long‐term SC hydration. DCLC use was not associated with changes in TEWL, skin pH, or microbiome biodiversity if compared to control. In Study 2, the 4‐week use of DCLC in combination with an emollient was well tolerated according to pediatrician skin assessment, and no flare‐ups were recorded. The microbiome biodiversity did not shift during the study. CONCLUSION: These findings support the use of DCLC in subjects with atopic‐prone skin.
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spelling pubmed-97964222022-12-30 A new dexpanthenol‐containing liquid cleanser for atopic‐prone skin: Results from two prospective clinical studies evaluating cutaneous tolerability, moisturization potential, and effects on barrier function Peltier, Erwan Trapp, Sonja de Salvo, Raffaella Sun, Connie Brandt, Marianne Laing, Sabrina Hennighausen, Natascha Barrionuevo‐Gonzalez, Ana J Cosmet Dermatol Skin Care Articles BACKGROUND: Gentle cleansing of the skin without further compromising its barrier function and moisture content and being simultaneously devoid of adverse effects on the skin microbiome are important features of body cleansers for atopic‐prone skin sufferers. For this population, a new dexpanthenol‐containing liquid cleanser (DCLC) was developed. METHODS: Two prospective 4‐week studies have been conducted. Study 1 investigated the effect of once‐daily DCLC on stratum corneum (SC) hydration, transepidermal water loss (TEWL), skin pH, and skin microbiome (all on the volar forearm) in adult subjects with dry skin (N = 44). Study 2 explored the cutaneous tolerability of DCLC and its effect on the microbiome biodiversity of the volar forearm skin in infants/children with atopic‐prone skin (N = 33, aged 6 months to 6 years). In the latter study, DCLC was applied 2–3 days/week in combination with an emollient applied at least twice daily. RESULTS: In Study 1, on Day 29, the mean change in skin surface capacitance from baseline was significantly greater in the forearm test area treated with DCLC than in the contralateral test area (control) treated with water only (5.16 vs. 3.65 a.u.; p = 0.011), suggesting long‐term SC hydration. DCLC use was not associated with changes in TEWL, skin pH, or microbiome biodiversity if compared to control. In Study 2, the 4‐week use of DCLC in combination with an emollient was well tolerated according to pediatrician skin assessment, and no flare‐ups were recorded. The microbiome biodiversity did not shift during the study. CONCLUSION: These findings support the use of DCLC in subjects with atopic‐prone skin. John Wiley and Sons Inc. 2022-07-31 2022-09 /pmc/articles/PMC9796422/ /pubmed/35866315 http://dx.doi.org/10.1111/jocd.15252 Text en © 2022 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Skin Care Articles
Peltier, Erwan
Trapp, Sonja
de Salvo, Raffaella
Sun, Connie
Brandt, Marianne
Laing, Sabrina
Hennighausen, Natascha
Barrionuevo‐Gonzalez, Ana
A new dexpanthenol‐containing liquid cleanser for atopic‐prone skin: Results from two prospective clinical studies evaluating cutaneous tolerability, moisturization potential, and effects on barrier function
title A new dexpanthenol‐containing liquid cleanser for atopic‐prone skin: Results from two prospective clinical studies evaluating cutaneous tolerability, moisturization potential, and effects on barrier function
title_full A new dexpanthenol‐containing liquid cleanser for atopic‐prone skin: Results from two prospective clinical studies evaluating cutaneous tolerability, moisturization potential, and effects on barrier function
title_fullStr A new dexpanthenol‐containing liquid cleanser for atopic‐prone skin: Results from two prospective clinical studies evaluating cutaneous tolerability, moisturization potential, and effects on barrier function
title_full_unstemmed A new dexpanthenol‐containing liquid cleanser for atopic‐prone skin: Results from two prospective clinical studies evaluating cutaneous tolerability, moisturization potential, and effects on barrier function
title_short A new dexpanthenol‐containing liquid cleanser for atopic‐prone skin: Results from two prospective clinical studies evaluating cutaneous tolerability, moisturization potential, and effects on barrier function
title_sort new dexpanthenol‐containing liquid cleanser for atopic‐prone skin: results from two prospective clinical studies evaluating cutaneous tolerability, moisturization potential, and effects on barrier function
topic Skin Care Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796422/
https://www.ncbi.nlm.nih.gov/pubmed/35866315
http://dx.doi.org/10.1111/jocd.15252
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