Feasibility of Magnetic Resonance‐Guided High‐Intensity‐Focused Ultrasound (MRgHIFU) Ablation of Stump Neuromas for the Relief of Chronic Postamputation Neuropathic Pain

Up to 70% of limb amputees develop chronic postamputation neuropathic pain (CPANP) which includes phantom pain and residual limb neuropathic pain due to neuroma formation. CPANP often requires invasive procedures aimed at neuroma ablation. Five amputees received 6 noninvasive magnetic resonance‐guid...

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Autores principales: Nachtigal, Alicia, Cozakov, Ronen, Grinfeld, Anat, Haddad, May, Eisenberg, Elon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Case Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796504/
https://www.ncbi.nlm.nih.gov/pubmed/35633227
http://dx.doi.org/10.1002/jum.16026
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author Nachtigal, Alicia
Cozakov, Ronen
Grinfeld, Anat
Haddad, May
Eisenberg, Elon
author_facet Nachtigal, Alicia
Cozakov, Ronen
Grinfeld, Anat
Haddad, May
Eisenberg, Elon
author_sort Nachtigal, Alicia
collection PubMed
description Up to 70% of limb amputees develop chronic postamputation neuropathic pain (CPANP) which includes phantom pain and residual limb neuropathic pain due to neuroma formation. CPANP often requires invasive procedures aimed at neuroma ablation. Five amputees received 6 noninvasive magnetic resonance‐guided high‐intensity‐focused ultrasound MRgHIFU treatments ExAblate®, Insightec, Tirat‐Carmel, Israel). Although ablative temperature (>65°C) at the neuroma was reached in only 1 patient, pain intensity dropped from 5.7 at baseline to 4.3 and back to 5.6 at 3 and 6 month follow‐up. Post‐treatment bone necrosis was demonstrated in 1 patient. Although no firm conclusion about the effectiveness of MRgHIFU for CPANP could be drawn, further studies are warranted.
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spelling pubmed-97965042022-12-30 Feasibility of Magnetic Resonance‐Guided High‐Intensity‐Focused Ultrasound (MRgHIFU) Ablation of Stump Neuromas for the Relief of Chronic Postamputation Neuropathic Pain Nachtigal, Alicia Cozakov, Ronen Grinfeld, Anat Haddad, May Eisenberg, Elon J Ultrasound Med Case Series Up to 70% of limb amputees develop chronic postamputation neuropathic pain (CPANP) which includes phantom pain and residual limb neuropathic pain due to neuroma formation. CPANP often requires invasive procedures aimed at neuroma ablation. Five amputees received 6 noninvasive magnetic resonance‐guided high‐intensity‐focused ultrasound MRgHIFU treatments ExAblate®, Insightec, Tirat‐Carmel, Israel). Although ablative temperature (>65°C) at the neuroma was reached in only 1 patient, pain intensity dropped from 5.7 at baseline to 4.3 and back to 5.6 at 3 and 6 month follow‐up. Post‐treatment bone necrosis was demonstrated in 1 patient. Although no firm conclusion about the effectiveness of MRgHIFU for CPANP could be drawn, further studies are warranted. John Wiley & Sons, Inc. 2022-05-28 2022-12 /pmc/articles/PMC9796504/ /pubmed/35633227 http://dx.doi.org/10.1002/jum.16026 Text en © 2022 The Authors. Journal of Ultrasound in Medicine published by Wiley Periodicals LLC on behalf of American Institute of Ultrasound in Medicine. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Series
Nachtigal, Alicia
Cozakov, Ronen
Grinfeld, Anat
Haddad, May
Eisenberg, Elon
Feasibility of Magnetic Resonance‐Guided High‐Intensity‐Focused Ultrasound (MRgHIFU) Ablation of Stump Neuromas for the Relief of Chronic Postamputation Neuropathic Pain
title Feasibility of Magnetic Resonance‐Guided High‐Intensity‐Focused Ultrasound (MRgHIFU) Ablation of Stump Neuromas for the Relief of Chronic Postamputation Neuropathic Pain
title_full Feasibility of Magnetic Resonance‐Guided High‐Intensity‐Focused Ultrasound (MRgHIFU) Ablation of Stump Neuromas for the Relief of Chronic Postamputation Neuropathic Pain
title_fullStr Feasibility of Magnetic Resonance‐Guided High‐Intensity‐Focused Ultrasound (MRgHIFU) Ablation of Stump Neuromas for the Relief of Chronic Postamputation Neuropathic Pain
title_full_unstemmed Feasibility of Magnetic Resonance‐Guided High‐Intensity‐Focused Ultrasound (MRgHIFU) Ablation of Stump Neuromas for the Relief of Chronic Postamputation Neuropathic Pain
title_short Feasibility of Magnetic Resonance‐Guided High‐Intensity‐Focused Ultrasound (MRgHIFU) Ablation of Stump Neuromas for the Relief of Chronic Postamputation Neuropathic Pain
title_sort feasibility of magnetic resonance‐guided high‐intensity‐focused ultrasound (mrghifu) ablation of stump neuromas for the relief of chronic postamputation neuropathic pain
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796504/
https://www.ncbi.nlm.nih.gov/pubmed/35633227
http://dx.doi.org/10.1002/jum.16026
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