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Surveys of clinician and patient attitudes to an add‐on for in vitro fertilisation

BACKGROUND: Add‐ons at the time of in vitro fertilisation (IVF) have become commonplace, despite a general lack of evidence that they are effective and safe. The ‘Colorado Protocol’ is a commonly used add‐on consisting of aspirin, steroid and an antibiotic. Before commencing planning for a clinical...

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Autores principales: Anderson, Karyn, Blaxall, Michelle, Lensen, Sarah, Farquhar, Cindy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796505/
https://www.ncbi.nlm.nih.gov/pubmed/35726738
http://dx.doi.org/10.1111/ajo.13576
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author Anderson, Karyn
Blaxall, Michelle
Lensen, Sarah
Farquhar, Cindy
author_facet Anderson, Karyn
Blaxall, Michelle
Lensen, Sarah
Farquhar, Cindy
author_sort Anderson, Karyn
collection PubMed
description BACKGROUND: Add‐ons at the time of in vitro fertilisation (IVF) have become commonplace, despite a general lack of evidence that they are effective and safe. The ‘Colorado Protocol’ is a commonly used add‐on consisting of aspirin, steroid and an antibiotic. Before commencing planning for a clinical trial evaluating the Colorado Protocol, researchers and funders need evidence that the Colorado Protocol is being prescribed, and to be assured that sufficient numbers of participants can be recruited for a clinical trial. AIMS: To survey fertility clinicians and patients on attitudes toward use of add‐ons during IVF, willingness of patients to be randomly assigned to an add‐on trial treatment or placebo, and what would be the clinically meaningful outcomes, using the Colorado Protocol as a test case. MATERIALS AND METHODS: Two online surveys were conducted: clinicians from fertility clinics across the United Kingdom, Australia, and New Zealand; and patients from Auckland‐based clinics and NZ patient support groups. RESULTS: Of 58 clinicians, 44 (75%) had recommended an add‐on within the preceding year. Thirty‐nine (67%) clinicians were aware of the Colorado Protocol, with 17 (29%) having recommended it within the preceding year. Of the 289 patients, 80% indicated willingness to take trial medications during IVF, and 68% were willing to be randomly assigned to the placebo arm of a trial. The median perceived minimum clinically important difference in live births in both samples was 5%. CONCLUSIONS: A future trial of this add‐on in IVF would be supported by patients in the context of the New Zealand fertility healthcare system.
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spelling pubmed-97965052022-12-30 Surveys of clinician and patient attitudes to an add‐on for in vitro fertilisation Anderson, Karyn Blaxall, Michelle Lensen, Sarah Farquhar, Cindy Aust N Z J Obstet Gynaecol Original Articles BACKGROUND: Add‐ons at the time of in vitro fertilisation (IVF) have become commonplace, despite a general lack of evidence that they are effective and safe. The ‘Colorado Protocol’ is a commonly used add‐on consisting of aspirin, steroid and an antibiotic. Before commencing planning for a clinical trial evaluating the Colorado Protocol, researchers and funders need evidence that the Colorado Protocol is being prescribed, and to be assured that sufficient numbers of participants can be recruited for a clinical trial. AIMS: To survey fertility clinicians and patients on attitudes toward use of add‐ons during IVF, willingness of patients to be randomly assigned to an add‐on trial treatment or placebo, and what would be the clinically meaningful outcomes, using the Colorado Protocol as a test case. MATERIALS AND METHODS: Two online surveys were conducted: clinicians from fertility clinics across the United Kingdom, Australia, and New Zealand; and patients from Auckland‐based clinics and NZ patient support groups. RESULTS: Of 58 clinicians, 44 (75%) had recommended an add‐on within the preceding year. Thirty‐nine (67%) clinicians were aware of the Colorado Protocol, with 17 (29%) having recommended it within the preceding year. Of the 289 patients, 80% indicated willingness to take trial medications during IVF, and 68% were willing to be randomly assigned to the placebo arm of a trial. The median perceived minimum clinically important difference in live births in both samples was 5%. CONCLUSIONS: A future trial of this add‐on in IVF would be supported by patients in the context of the New Zealand fertility healthcare system. John Wiley and Sons Inc. 2022-06-21 2022-10 /pmc/articles/PMC9796505/ /pubmed/35726738 http://dx.doi.org/10.1111/ajo.13576 Text en © 2022 The Authors. Australian and New Zealand Journal of Obstetrics and Gynaecology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Obstetricians and Gynaecologists. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Anderson, Karyn
Blaxall, Michelle
Lensen, Sarah
Farquhar, Cindy
Surveys of clinician and patient attitudes to an add‐on for in vitro fertilisation
title Surveys of clinician and patient attitudes to an add‐on for in vitro fertilisation
title_full Surveys of clinician and patient attitudes to an add‐on for in vitro fertilisation
title_fullStr Surveys of clinician and patient attitudes to an add‐on for in vitro fertilisation
title_full_unstemmed Surveys of clinician and patient attitudes to an add‐on for in vitro fertilisation
title_short Surveys of clinician and patient attitudes to an add‐on for in vitro fertilisation
title_sort surveys of clinician and patient attitudes to an add‐on for in vitro fertilisation
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796505/
https://www.ncbi.nlm.nih.gov/pubmed/35726738
http://dx.doi.org/10.1111/ajo.13576
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