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Suspected benzodiazepine withdrawal‐associated seizures in 3 young dogs undergoing mechanical ventilation
OBJECTIVE: To describe new onset of generalized seizures in 3 young dogs following cessation of a benzodiazepine‐containing sedation protocol to facilitate mechanical ventilation (MV) for hypoxemia. SERIES SUMMARY: Three dogs under 5 months of age underwent MV due to severe hypoxemia. All 3 dogs wer...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796509/ https://www.ncbi.nlm.nih.gov/pubmed/35708738 http://dx.doi.org/10.1111/vec.13221 |
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author | Walton, Rebecca A. L. Enders, Brittany D. |
author_facet | Walton, Rebecca A. L. Enders, Brittany D. |
author_sort | Walton, Rebecca A. L. |
collection | PubMed |
description | OBJECTIVE: To describe new onset of generalized seizures in 3 young dogs following cessation of a benzodiazepine‐containing sedation protocol to facilitate mechanical ventilation (MV) for hypoxemia. SERIES SUMMARY: Three dogs under 5 months of age underwent MV due to severe hypoxemia. All 3 dogs were sedated with a constant rate infusion of benzodiazepines as part of their sedation protocol to facilitate MV. All 3 dogs had an acute onset of generalized seizures within 36 hours of sedation cessation and weaning from MV. All 3 dogs’ seizures were successfully managed with a slow, tapering course of benzodiazepines. One dog was additionally treated with levetiracetam at the time of initial seizure activity, which was discontinued 1 year following discharge and absence of ongoing seizure activity. All 3 dogs were discharged successfully with no reports of ongoing seizures or neurologic deficits after discharge. NEW OR UNIQUE INFORMATION PROVIDED: Young dogs managed with benzodiazepines to facilitate MV may have acute onset of generalized seizures following cessation, which can be successfully managed with short‐term benzodiazepine therapy. The 3 cases in this series demonstrated a positive outcome and were successfully managed following acute onset of generalized seizure activity post‐MV. |
format | Online Article Text |
id | pubmed-9796509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97965092022-12-30 Suspected benzodiazepine withdrawal‐associated seizures in 3 young dogs undergoing mechanical ventilation Walton, Rebecca A. L. Enders, Brittany D. J Vet Emerg Crit Care (San Antonio) Case Series OBJECTIVE: To describe new onset of generalized seizures in 3 young dogs following cessation of a benzodiazepine‐containing sedation protocol to facilitate mechanical ventilation (MV) for hypoxemia. SERIES SUMMARY: Three dogs under 5 months of age underwent MV due to severe hypoxemia. All 3 dogs were sedated with a constant rate infusion of benzodiazepines as part of their sedation protocol to facilitate MV. All 3 dogs had an acute onset of generalized seizures within 36 hours of sedation cessation and weaning from MV. All 3 dogs’ seizures were successfully managed with a slow, tapering course of benzodiazepines. One dog was additionally treated with levetiracetam at the time of initial seizure activity, which was discontinued 1 year following discharge and absence of ongoing seizure activity. All 3 dogs were discharged successfully with no reports of ongoing seizures or neurologic deficits after discharge. NEW OR UNIQUE INFORMATION PROVIDED: Young dogs managed with benzodiazepines to facilitate MV may have acute onset of generalized seizures following cessation, which can be successfully managed with short‐term benzodiazepine therapy. The 3 cases in this series demonstrated a positive outcome and were successfully managed following acute onset of generalized seizure activity post‐MV. John Wiley and Sons Inc. 2022-06-16 2022 /pmc/articles/PMC9796509/ /pubmed/35708738 http://dx.doi.org/10.1111/vec.13221 Text en © 2022 The Authors. Journal of Veterinary Emergency and Critical Care published by Wiley Periodicals LLC on behalf of Veterinary Emergency and Critical Care Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Case Series Walton, Rebecca A. L. Enders, Brittany D. Suspected benzodiazepine withdrawal‐associated seizures in 3 young dogs undergoing mechanical ventilation |
title | Suspected benzodiazepine withdrawal‐associated seizures in 3 young dogs undergoing mechanical ventilation |
title_full | Suspected benzodiazepine withdrawal‐associated seizures in 3 young dogs undergoing mechanical ventilation |
title_fullStr | Suspected benzodiazepine withdrawal‐associated seizures in 3 young dogs undergoing mechanical ventilation |
title_full_unstemmed | Suspected benzodiazepine withdrawal‐associated seizures in 3 young dogs undergoing mechanical ventilation |
title_short | Suspected benzodiazepine withdrawal‐associated seizures in 3 young dogs undergoing mechanical ventilation |
title_sort | suspected benzodiazepine withdrawal‐associated seizures in 3 young dogs undergoing mechanical ventilation |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796509/ https://www.ncbi.nlm.nih.gov/pubmed/35708738 http://dx.doi.org/10.1111/vec.13221 |
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