Cargando…
Familial risk of postpartum depression
OBJECTIVE: Many psychiatric diseases have a strong familial aggregation, but it is unknown whether postpartum depression (PPD) without prior psychiatric history aggregates in families. METHODS: Based on Danish national registers, we constructed a cohort with information on 848,544 singleton deliveri...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796634/ https://www.ncbi.nlm.nih.gov/pubmed/35731191 http://dx.doi.org/10.1111/acps.13465 |
_version_ | 1784860531056705536 |
---|---|
author | Rasmussen, Marie‐Louise H. Poulsen, Gry J. Wohlfahrt, Jan Videbech, Poul Melbye, Mads |
author_facet | Rasmussen, Marie‐Louise H. Poulsen, Gry J. Wohlfahrt, Jan Videbech, Poul Melbye, Mads |
author_sort | Rasmussen, Marie‐Louise H. |
collection | PubMed |
description | OBJECTIVE: Many psychiatric diseases have a strong familial aggregation, but it is unknown whether postpartum depression (PPD) without prior psychiatric history aggregates in families. METHODS: Based on Danish national registers, we constructed a cohort with information on 848,544 singleton deliveries (1996–2017). Women with an episode of PPD were defined as having used antidepressant medication and/or had a hospital contact for depression within 6 months after delivery. Those with psychiatric history prior to the delivery were excluded. We estimated relative risk (RR) of PPD, comparing women with female relatives with and without PPD history, respectively. RESULTS: Overall, women with a PPD history in female blood relatives had themselves a higher risk of PPD (RR = 1.64, 95% CI 1.16–2.34). Having the first‐degree female relative with PPD history was associated with a more than 2.5 times (RR = 2.65, 95% CI 1.79–3.91) increased risk of PPD. However, having the second/third‐degree female relative and/or a female non‐blood relative with PPD history did not increase the woman's own risk of PPD (RR = 0.58, 95% CI 0.26–1.28, RR = 1.09, 95% CI 0.83–1.44). CONCLUSION: Postpartum depression aggregates in families with no other psychiatric history, but the findings do not support a strong genetic trait as a major cause. Other possible mechanisms are shared environment and/or health‐seeking behavior in close relationships. |
format | Online Article Text |
id | pubmed-9796634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97966342022-12-30 Familial risk of postpartum depression Rasmussen, Marie‐Louise H. Poulsen, Gry J. Wohlfahrt, Jan Videbech, Poul Melbye, Mads Acta Psychiatr Scand Original Articles OBJECTIVE: Many psychiatric diseases have a strong familial aggregation, but it is unknown whether postpartum depression (PPD) without prior psychiatric history aggregates in families. METHODS: Based on Danish national registers, we constructed a cohort with information on 848,544 singleton deliveries (1996–2017). Women with an episode of PPD were defined as having used antidepressant medication and/or had a hospital contact for depression within 6 months after delivery. Those with psychiatric history prior to the delivery were excluded. We estimated relative risk (RR) of PPD, comparing women with female relatives with and without PPD history, respectively. RESULTS: Overall, women with a PPD history in female blood relatives had themselves a higher risk of PPD (RR = 1.64, 95% CI 1.16–2.34). Having the first‐degree female relative with PPD history was associated with a more than 2.5 times (RR = 2.65, 95% CI 1.79–3.91) increased risk of PPD. However, having the second/third‐degree female relative and/or a female non‐blood relative with PPD history did not increase the woman's own risk of PPD (RR = 0.58, 95% CI 0.26–1.28, RR = 1.09, 95% CI 0.83–1.44). CONCLUSION: Postpartum depression aggregates in families with no other psychiatric history, but the findings do not support a strong genetic trait as a major cause. Other possible mechanisms are shared environment and/or health‐seeking behavior in close relationships. John Wiley and Sons Inc. 2022-07-25 2022-10 /pmc/articles/PMC9796634/ /pubmed/35731191 http://dx.doi.org/10.1111/acps.13465 Text en © 2022 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Rasmussen, Marie‐Louise H. Poulsen, Gry J. Wohlfahrt, Jan Videbech, Poul Melbye, Mads Familial risk of postpartum depression |
title | Familial risk of postpartum depression |
title_full | Familial risk of postpartum depression |
title_fullStr | Familial risk of postpartum depression |
title_full_unstemmed | Familial risk of postpartum depression |
title_short | Familial risk of postpartum depression |
title_sort | familial risk of postpartum depression |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796634/ https://www.ncbi.nlm.nih.gov/pubmed/35731191 http://dx.doi.org/10.1111/acps.13465 |
work_keys_str_mv | AT rasmussenmarielouiseh familialriskofpostpartumdepression AT poulsengryj familialriskofpostpartumdepression AT wohlfahrtjan familialriskofpostpartumdepression AT videbechpoul familialriskofpostpartumdepression AT melbyemads familialriskofpostpartumdepression |