Exploring the potential of exosomes in diagnosis and drug delivery for pancreatic ductal adenocarcinoma

Pancreatic cancer (PC) is a cancer of the digestive system, and pancreatic ductal adenocarcinoma (PDAC) accounts for approximately 90% of all PC cases. Exosomes derived from PDAC (PDAC‐exosomes) promote PDAC development and metastasis. Exosomes are nanoscale vesicles secreted by most cells, which ca...

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Detalles Bibliográficos
Autores principales: Xu, Biaoming, Chen, Yu, Peng, Mingjing, Zheng, Jin Hai, Zuo, Chaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796664/
https://www.ncbi.nlm.nih.gov/pubmed/35765844
http://dx.doi.org/10.1002/ijc.34195
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author Xu, Biaoming
Chen, Yu
Peng, Mingjing
Zheng, Jin Hai
Zuo, Chaohui
author_facet Xu, Biaoming
Chen, Yu
Peng, Mingjing
Zheng, Jin Hai
Zuo, Chaohui
author_sort Xu, Biaoming
collection PubMed
description Pancreatic cancer (PC) is a cancer of the digestive system, and pancreatic ductal adenocarcinoma (PDAC) accounts for approximately 90% of all PC cases. Exosomes derived from PDAC (PDAC‐exosomes) promote PDAC development and metastasis. Exosomes are nanoscale vesicles secreted by most cells, which can carry biologically active molecules and mediate communication and cargo transportation among cells. Recent studies have focused on transforming exosomes into good drug delivery systems (DDSs) to improve the clinical treatment of PDAC. This review considers PDAC as the main research object to introduce the role of PDAC‐exosomes in PDAC development and metastasis. This review focuses on the following two themes: (a) the great potential of PDAC‐exosomes as new diagnostic markers for PDAC, and (b) the transformation of exosomes into potential DDSs.
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spelling pubmed-97966642023-01-04 Exploring the potential of exosomes in diagnosis and drug delivery for pancreatic ductal adenocarcinoma Xu, Biaoming Chen, Yu Peng, Mingjing Zheng, Jin Hai Zuo, Chaohui Int J Cancer Review Pancreatic cancer (PC) is a cancer of the digestive system, and pancreatic ductal adenocarcinoma (PDAC) accounts for approximately 90% of all PC cases. Exosomes derived from PDAC (PDAC‐exosomes) promote PDAC development and metastasis. Exosomes are nanoscale vesicles secreted by most cells, which can carry biologically active molecules and mediate communication and cargo transportation among cells. Recent studies have focused on transforming exosomes into good drug delivery systems (DDSs) to improve the clinical treatment of PDAC. This review considers PDAC as the main research object to introduce the role of PDAC‐exosomes in PDAC development and metastasis. This review focuses on the following two themes: (a) the great potential of PDAC‐exosomes as new diagnostic markers for PDAC, and (b) the transformation of exosomes into potential DDSs. John Wiley & Sons, Inc. 2022-07-13 2023-01-15 /pmc/articles/PMC9796664/ /pubmed/35765844 http://dx.doi.org/10.1002/ijc.34195 Text en © 2022 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review
Xu, Biaoming
Chen, Yu
Peng, Mingjing
Zheng, Jin Hai
Zuo, Chaohui
Exploring the potential of exosomes in diagnosis and drug delivery for pancreatic ductal adenocarcinoma
title Exploring the potential of exosomes in diagnosis and drug delivery for pancreatic ductal adenocarcinoma
title_full Exploring the potential of exosomes in diagnosis and drug delivery for pancreatic ductal adenocarcinoma
title_fullStr Exploring the potential of exosomes in diagnosis and drug delivery for pancreatic ductal adenocarcinoma
title_full_unstemmed Exploring the potential of exosomes in diagnosis and drug delivery for pancreatic ductal adenocarcinoma
title_short Exploring the potential of exosomes in diagnosis and drug delivery for pancreatic ductal adenocarcinoma
title_sort exploring the potential of exosomes in diagnosis and drug delivery for pancreatic ductal adenocarcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796664/
https://www.ncbi.nlm.nih.gov/pubmed/35765844
http://dx.doi.org/10.1002/ijc.34195
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