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Association of peptidoglycan recognition protein 1 to post‐myocardial infarction and periodontal inflammation: A subgroup report from the PAROKRANK (Periodontal Disease and the Relation to Myocardial Infarction) study

BACKGROUND: Peptidoglycan recognition protein 1 (PGLYRP1) is an antimicrobial and proinflammatory innate immunity protein activated during infections. We aimed to investigate whether PGYLRP1 and associated molecules of the immune response in saliva is a cumulative outcome result of both MI and perio...

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Autores principales: Rathnayake, Nilminie, Gustafsson, Anders, Sorsa, Timo, Norhammar, Anna, Bostanci, Nagihan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796725/
https://www.ncbi.nlm.nih.gov/pubmed/35344208
http://dx.doi.org/10.1002/JPER.21-0595
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author Rathnayake, Nilminie
Gustafsson, Anders
Sorsa, Timo
Norhammar, Anna
Bostanci, Nagihan
author_facet Rathnayake, Nilminie
Gustafsson, Anders
Sorsa, Timo
Norhammar, Anna
Bostanci, Nagihan
author_sort Rathnayake, Nilminie
collection PubMed
description BACKGROUND: Peptidoglycan recognition protein 1 (PGLYRP1) is an antimicrobial and proinflammatory innate immunity protein activated during infections. We aimed to investigate whether PGYLRP1 and associated molecules of the immune response in saliva is a cumulative outcome result of both MI and periodontal inflammation. METHODS AND RESULTS: Two hundred patients with MI and another 200 matched non‐MI controls were included. A full‐mouthexamination was conducted to assess periodontal inflammation and collection of stimulated saliva was performed 6 to 10 weeks after the first MI. PGLYRP1, triggering receptor expressed on myeloid cells 1 (TREM‐1), interleukin‐1 beta (IL‐1β) were analyzed by ELISA. Matrix metalloproteinase (MMP)‐8 levels were determined by IFMA. Compared to controls, MI patients showed higher salivary PGLYRP1, but not TREM‐1 levels. The difference in PGLYRP1 levels remained after adjustment for covariates. In MI patients, the PGLYRP1 levels positively correlated with BOP and PPD 4 to 5 mm. Among non‐MI subjects, the levels of PGLYRP1 correlated positively and significantly with BOP and total PPD. Salivary PGLYRP1 concentrations also showed strong positive correlations with levels of TREM‐1, IL‐1β and MMP‐8. In multivariate linear regression analysis, in MI patients, BOP and former smokingstatus displayed an association with salivary PGLYRP1 concentration. CONCLUSION: MI patients showed higher salivary PGLYRP1 levels than healthy controls, also after adjusting for smoking, sex, age and periodontal health status. Salivary levels of PGLYRP1 may reflect the overall inflammatory burden to chronic bacterial exposure, possibly underpinning the observed associations between periodontitis and exposure with MI.
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spelling pubmed-97967252023-01-04 Association of peptidoglycan recognition protein 1 to post‐myocardial infarction and periodontal inflammation: A subgroup report from the PAROKRANK (Periodontal Disease and the Relation to Myocardial Infarction) study Rathnayake, Nilminie Gustafsson, Anders Sorsa, Timo Norhammar, Anna Bostanci, Nagihan J Periodontol Clinical Science BACKGROUND: Peptidoglycan recognition protein 1 (PGLYRP1) is an antimicrobial and proinflammatory innate immunity protein activated during infections. We aimed to investigate whether PGYLRP1 and associated molecules of the immune response in saliva is a cumulative outcome result of both MI and periodontal inflammation. METHODS AND RESULTS: Two hundred patients with MI and another 200 matched non‐MI controls were included. A full‐mouthexamination was conducted to assess periodontal inflammation and collection of stimulated saliva was performed 6 to 10 weeks after the first MI. PGLYRP1, triggering receptor expressed on myeloid cells 1 (TREM‐1), interleukin‐1 beta (IL‐1β) were analyzed by ELISA. Matrix metalloproteinase (MMP)‐8 levels were determined by IFMA. Compared to controls, MI patients showed higher salivary PGLYRP1, but not TREM‐1 levels. The difference in PGLYRP1 levels remained after adjustment for covariates. In MI patients, the PGLYRP1 levels positively correlated with BOP and PPD 4 to 5 mm. Among non‐MI subjects, the levels of PGLYRP1 correlated positively and significantly with BOP and total PPD. Salivary PGLYRP1 concentrations also showed strong positive correlations with levels of TREM‐1, IL‐1β and MMP‐8. In multivariate linear regression analysis, in MI patients, BOP and former smokingstatus displayed an association with salivary PGLYRP1 concentration. CONCLUSION: MI patients showed higher salivary PGLYRP1 levels than healthy controls, also after adjusting for smoking, sex, age and periodontal health status. Salivary levels of PGLYRP1 may reflect the overall inflammatory burden to chronic bacterial exposure, possibly underpinning the observed associations between periodontitis and exposure with MI. John Wiley and Sons Inc. 2022-07-19 2022-09 /pmc/articles/PMC9796725/ /pubmed/35344208 http://dx.doi.org/10.1002/JPER.21-0595 Text en © 2022 The Authors. Journal of Periodontology published by Wiley Periodicals LLC on behalf of American Academy of Periodontology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Clinical Science
Rathnayake, Nilminie
Gustafsson, Anders
Sorsa, Timo
Norhammar, Anna
Bostanci, Nagihan
Association of peptidoglycan recognition protein 1 to post‐myocardial infarction and periodontal inflammation: A subgroup report from the PAROKRANK (Periodontal Disease and the Relation to Myocardial Infarction) study
title Association of peptidoglycan recognition protein 1 to post‐myocardial infarction and periodontal inflammation: A subgroup report from the PAROKRANK (Periodontal Disease and the Relation to Myocardial Infarction) study
title_full Association of peptidoglycan recognition protein 1 to post‐myocardial infarction and periodontal inflammation: A subgroup report from the PAROKRANK (Periodontal Disease and the Relation to Myocardial Infarction) study
title_fullStr Association of peptidoglycan recognition protein 1 to post‐myocardial infarction and periodontal inflammation: A subgroup report from the PAROKRANK (Periodontal Disease and the Relation to Myocardial Infarction) study
title_full_unstemmed Association of peptidoglycan recognition protein 1 to post‐myocardial infarction and periodontal inflammation: A subgroup report from the PAROKRANK (Periodontal Disease and the Relation to Myocardial Infarction) study
title_short Association of peptidoglycan recognition protein 1 to post‐myocardial infarction and periodontal inflammation: A subgroup report from the PAROKRANK (Periodontal Disease and the Relation to Myocardial Infarction) study
title_sort association of peptidoglycan recognition protein 1 to post‐myocardial infarction and periodontal inflammation: a subgroup report from the parokrank (periodontal disease and the relation to myocardial infarction) study
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796725/
https://www.ncbi.nlm.nih.gov/pubmed/35344208
http://dx.doi.org/10.1002/JPER.21-0595
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