α‐Synuclein V15A Variant in Familial Parkinson's Disease Exhibits a Weaker Lipid‐Binding Property

BACKGROUND: The α‐Synuclein (α‐Syn) V15A variant has been found in two Caucasian families with Parkinson's disease (PD). However, the significance of this missense variant remained unclear. OBJECTIVE: We sought to elucidate whether V15A could increase aggregation or change phospholipid affinity...

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Detalles Bibliográficos
Autores principales: Daida, Kensuke, Shimonaka, Shotaro, Shiba‐Fukushima, Kahori, Ogata, Jun, Yoshino, Hiroyo, Okuzumi, Ayami, Hatano, Taku, Motoi, Yumiko, Hirunagi, Tomoki, Katsuno, Masahisa, Shindou, Hideo, Funayama, Manabu, Nishioka, Kenya, Hattori, Nobutaka, Imai, Yuzuru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Regular Issue Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796804/
https://www.ncbi.nlm.nih.gov/pubmed/35894540
http://dx.doi.org/10.1002/mds.29162

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