Genome wide CRISPR screen for Pasteurella multocida toxin (PMT) binding proteins reveals LDL Receptor Related Protein 1 (LRP1) as crucial cellular receptor

PMT is a protein toxin produced by Pasteurella multocida serotypes A and D. As causative agent of atrophic rhinitis in swine, it leads to rapid degradation of the nasal turbinate bone. The toxin acts as a deamidase to modify a crucial glutamine in heterotrimeric G proteins, which results in constitu...

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Detalles Bibliográficos
Autores principales: Schoellkopf, Julian, Mueller, Thomas, Hippchen, Lena, Mueller, Teresa, Reuten, Raphael, Backofen, Rolf, Orth, Joachim, Schmidt, Gudula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797058/
https://www.ncbi.nlm.nih.gov/pubmed/36516199
http://dx.doi.org/10.1371/journal.ppat.1010781

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