Molecular identification of bulbospinal ON neurons by GPER, which drives pain and morphine tolerance

The rostral ventromedial medulla (RVM) exerts bidirectional descending modulation of pain attributable to the activity of electrophysiologically identified pronociceptive ON and antinociceptive OFF neurons. Here, we report that GABAergic ON neurons specifically express G protein–coupled estrogen rec...

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Detalles Bibliográficos
Autores principales: Jiao, Yingfu, Gao, Po, Dong, Li, Ding, Xiaowei, Meng, Youqiang, Qian, Jiahong, Gao, Ting, Wang, Ruoxi, Jiang, Tao, Zhang, Yunchun, Kong, Dexu, Wu, Yi, Chen, Sihan, Xu, Saihong, Tang, Dan, Luo, Ping, Wu, Meimei, Meng, Li, Wen, Daxiang, Wu, Changhao, Zhang, Guohua, Shi, Xueyin, Yu, Weifeng, Rong, Weifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797334/
https://www.ncbi.nlm.nih.gov/pubmed/36346677
http://dx.doi.org/10.1172/JCI154588

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