Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models

Signaling circuits crucial to systemic physiology are widespread, yet uncovering their molecular underpinnings remains a barrier to understanding the etiology of many metabolic disorders. Here, we identified a copper-linked signaling circuit activated by disruption of mitochondrial function in the m...

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Detalles Bibliográficos
Autores principales: Jett, Kimberly A., Baker, Zakery N., Hossain, Amzad, Boulet, Aren, Cobine, Paul A., Ghosh, Sagnika, Ng, Philip, Yilmaz, Orhan, Barreto, Kris, DeCoteau, John, Mochoruk, Karen, Ioannou, George N., Savard, Christopher, Yuan, Sai, Abdalla, Osama H.M.H., Lowden, Christopher, Kim, Byung-Eun, Cheng, Hai-Ying Mary, Battersby, Brendan J., Gohil, Vishal M., Leary, Scot C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797342/
https://www.ncbi.nlm.nih.gov/pubmed/36301669
http://dx.doi.org/10.1172/JCI154684

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