Roles of the functional domains and conserved residues of the severe fever with thrombocytopenia syndrome virus L protein provide insights into the viral RNA transcription/replication mechanism

• All the domains of SFTSV-L protein were required for its function in viral RNA replication/transcription. • The influence of twelve conserved residues were evaluated, nine of which showed significance in the function of L protein. • Nine residues of SFTSV-L were strictly conserved among phleboviru...

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Autores principales: Yin, Zhiyun, Ren, Fuli, Zhou, Min, Chen, Shengyao, Deng, Yali, Hu, Sijing, Deng, Fei, Shen, Shu, Shi, Junming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797366/
https://www.ncbi.nlm.nih.gov/pubmed/36064095
http://dx.doi.org/10.1016/j.virs.2022.08.009
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author Yin, Zhiyun
Ren, Fuli
Zhou, Min
Chen, Shengyao
Deng, Yali
Hu, Sijing
Deng, Fei
Shen, Shu
Shi, Junming
author_facet Yin, Zhiyun
Ren, Fuli
Zhou, Min
Chen, Shengyao
Deng, Yali
Hu, Sijing
Deng, Fei
Shen, Shu
Shi, Junming
author_sort Yin, Zhiyun
collection PubMed
description • All the domains of SFTSV-L protein were required for its function in viral RNA replication/transcription. • The influence of twelve conserved residues were evaluated, nine of which showed significance in the function of L protein. • Nine residues of SFTSV-L were strictly conserved among phleboviruses, suggesting its potency as a promising drug target.
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spelling pubmed-97973662022-12-29 Roles of the functional domains and conserved residues of the severe fever with thrombocytopenia syndrome virus L protein provide insights into the viral RNA transcription/replication mechanism Yin, Zhiyun Ren, Fuli Zhou, Min Chen, Shengyao Deng, Yali Hu, Sijing Deng, Fei Shen, Shu Shi, Junming Virol Sin Letter • All the domains of SFTSV-L protein were required for its function in viral RNA replication/transcription. • The influence of twelve conserved residues were evaluated, nine of which showed significance in the function of L protein. • Nine residues of SFTSV-L were strictly conserved among phleboviruses, suggesting its potency as a promising drug target. Wuhan Institute of Virology, Chinese Academy of Sciences 2022-09-03 /pmc/articles/PMC9797366/ /pubmed/36064095 http://dx.doi.org/10.1016/j.virs.2022.08.009 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Letter
Yin, Zhiyun
Ren, Fuli
Zhou, Min
Chen, Shengyao
Deng, Yali
Hu, Sijing
Deng, Fei
Shen, Shu
Shi, Junming
Roles of the functional domains and conserved residues of the severe fever with thrombocytopenia syndrome virus L protein provide insights into the viral RNA transcription/replication mechanism
title Roles of the functional domains and conserved residues of the severe fever with thrombocytopenia syndrome virus L protein provide insights into the viral RNA transcription/replication mechanism
title_full Roles of the functional domains and conserved residues of the severe fever with thrombocytopenia syndrome virus L protein provide insights into the viral RNA transcription/replication mechanism
title_fullStr Roles of the functional domains and conserved residues of the severe fever with thrombocytopenia syndrome virus L protein provide insights into the viral RNA transcription/replication mechanism
title_full_unstemmed Roles of the functional domains and conserved residues of the severe fever with thrombocytopenia syndrome virus L protein provide insights into the viral RNA transcription/replication mechanism
title_short Roles of the functional domains and conserved residues of the severe fever with thrombocytopenia syndrome virus L protein provide insights into the viral RNA transcription/replication mechanism
title_sort roles of the functional domains and conserved residues of the severe fever with thrombocytopenia syndrome virus l protein provide insights into the viral rna transcription/replication mechanism
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797366/
https://www.ncbi.nlm.nih.gov/pubmed/36064095
http://dx.doi.org/10.1016/j.virs.2022.08.009
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