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Iron status and mental disorders: A Mendelian randomization study
BACKGROUND: Mental disorders account for an enormous global burden of disease, and has been associated with disturbed iron metabolism in observational studies. However, such associations are inconsistent and may be attributable to confounding from environmental factors. This study uses a two-sample...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797506/ https://www.ncbi.nlm.nih.gov/pubmed/36590208 http://dx.doi.org/10.3389/fnut.2022.1084860 |
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author | Qiu, Jiaqi Lian, Fuzhi Fang, Xuexian |
author_facet | Qiu, Jiaqi Lian, Fuzhi Fang, Xuexian |
author_sort | Qiu, Jiaqi |
collection | PubMed |
description | BACKGROUND: Mental disorders account for an enormous global burden of disease, and has been associated with disturbed iron metabolism in observational studies. However, such associations are inconsistent and may be attributable to confounding from environmental factors. This study uses a two-sample Mendelian randomization (MR) analysis to investigate whether there is any causal effect of systemic iron status on risk of 24 specific mental disorders. METHODS: Genetic variants with concordant relations to 4 biomarkers of iron status (serum iron, ferritin, transferrin saturation, and transferrin) were obtained from a genome-wide association study performed by the Genetics of Iron Status (GIS) consortium. Summary-level data for mental disorders were obtained from the UK Biobank. An inverse-variance weighted (IVW) approach was used for the main analysis, and the simple median, weighted median and MR-Egger methods were used in sensitivity analyses. RESULTS: Genetically predicted serum iron, ferritin, and transferrin saturation were positively associated with depression and psychogenic disorder, and inversely associated with gender identity disorders. A higher transferrin, indicative of lower iron status, was also associated with increased risk of gender identity disorders and decreased risk of psychogenic disorder. Results were broadly consistent when using multiple sensitivity analyses to account for potential genetic pleiotropy. CONCLUSION: Our findings offer a novel insight into mental health, highlighting a detrimental effect of higher iron status on depression and psychogenic disorder as well as a potential protective role on risk of gender identity disorders. Further studies regarding the underlying mechanisms are warranted for updating preventative strategies. |
format | Online Article Text |
id | pubmed-9797506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97975062022-12-30 Iron status and mental disorders: A Mendelian randomization study Qiu, Jiaqi Lian, Fuzhi Fang, Xuexian Front Nutr Nutrition BACKGROUND: Mental disorders account for an enormous global burden of disease, and has been associated with disturbed iron metabolism in observational studies. However, such associations are inconsistent and may be attributable to confounding from environmental factors. This study uses a two-sample Mendelian randomization (MR) analysis to investigate whether there is any causal effect of systemic iron status on risk of 24 specific mental disorders. METHODS: Genetic variants with concordant relations to 4 biomarkers of iron status (serum iron, ferritin, transferrin saturation, and transferrin) were obtained from a genome-wide association study performed by the Genetics of Iron Status (GIS) consortium. Summary-level data for mental disorders were obtained from the UK Biobank. An inverse-variance weighted (IVW) approach was used for the main analysis, and the simple median, weighted median and MR-Egger methods were used in sensitivity analyses. RESULTS: Genetically predicted serum iron, ferritin, and transferrin saturation were positively associated with depression and psychogenic disorder, and inversely associated with gender identity disorders. A higher transferrin, indicative of lower iron status, was also associated with increased risk of gender identity disorders and decreased risk of psychogenic disorder. Results were broadly consistent when using multiple sensitivity analyses to account for potential genetic pleiotropy. CONCLUSION: Our findings offer a novel insight into mental health, highlighting a detrimental effect of higher iron status on depression and psychogenic disorder as well as a potential protective role on risk of gender identity disorders. Further studies regarding the underlying mechanisms are warranted for updating preventative strategies. Frontiers Media S.A. 2022-12-15 /pmc/articles/PMC9797506/ /pubmed/36590208 http://dx.doi.org/10.3389/fnut.2022.1084860 Text en Copyright © 2022 Qiu, Lian and Fang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Qiu, Jiaqi Lian, Fuzhi Fang, Xuexian Iron status and mental disorders: A Mendelian randomization study |
title | Iron status and mental disorders: A Mendelian randomization study |
title_full | Iron status and mental disorders: A Mendelian randomization study |
title_fullStr | Iron status and mental disorders: A Mendelian randomization study |
title_full_unstemmed | Iron status and mental disorders: A Mendelian randomization study |
title_short | Iron status and mental disorders: A Mendelian randomization study |
title_sort | iron status and mental disorders: a mendelian randomization study |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797506/ https://www.ncbi.nlm.nih.gov/pubmed/36590208 http://dx.doi.org/10.3389/fnut.2022.1084860 |
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