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Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis

Nonalcoholic steatohepatitis (NASH) is the progressive form of nonalcoholic fatty liver disease (NAFLD), and the dysregulation of lipid metabolism and oxidative stress are the typical features. Subsequent dyslipidemia and oxygen radical production may render the formation of modified lipids. Macroph...

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Detalles Bibliográficos
Autores principales: Sheng, Wei, Ji, Guang, Zhang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797536/
https://www.ncbi.nlm.nih.gov/pubmed/36591228
http://dx.doi.org/10.3389/fimmu.2022.1050984
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author Sheng, Wei
Ji, Guang
Zhang, Li
author_facet Sheng, Wei
Ji, Guang
Zhang, Li
author_sort Sheng, Wei
collection PubMed
description Nonalcoholic steatohepatitis (NASH) is the progressive form of nonalcoholic fatty liver disease (NAFLD), and the dysregulation of lipid metabolism and oxidative stress are the typical features. Subsequent dyslipidemia and oxygen radical production may render the formation of modified lipids. Macrophage scavenger receptor 1 (MSR1) is responsible for the uptake of modified lipoprotein and is one of the key molecules in atherosclerosis. However, the unrestricted uptake of modified lipoproteins by MSR1 and the formation of cholesterol-rich foamy macrophages also can be observed in NASH patients and mouse models. In this review, we highlight the dysregulation of lipid metabolism and oxidative stress in NASH, the alteration of MSR1 expression in physiological and pathological conditions, the formation of modified lipoproteins, and the role of MSR1 on macrophage foaming and NASH development and progression.
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spelling pubmed-97975362022-12-30 Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis Sheng, Wei Ji, Guang Zhang, Li Front Immunol Immunology Nonalcoholic steatohepatitis (NASH) is the progressive form of nonalcoholic fatty liver disease (NAFLD), and the dysregulation of lipid metabolism and oxidative stress are the typical features. Subsequent dyslipidemia and oxygen radical production may render the formation of modified lipids. Macrophage scavenger receptor 1 (MSR1) is responsible for the uptake of modified lipoprotein and is one of the key molecules in atherosclerosis. However, the unrestricted uptake of modified lipoproteins by MSR1 and the formation of cholesterol-rich foamy macrophages also can be observed in NASH patients and mouse models. In this review, we highlight the dysregulation of lipid metabolism and oxidative stress in NASH, the alteration of MSR1 expression in physiological and pathological conditions, the formation of modified lipoproteins, and the role of MSR1 on macrophage foaming and NASH development and progression. Frontiers Media S.A. 2022-12-15 /pmc/articles/PMC9797536/ /pubmed/36591228 http://dx.doi.org/10.3389/fimmu.2022.1050984 Text en Copyright © 2022 Sheng, Ji and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Sheng, Wei
Ji, Guang
Zhang, Li
Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis
title Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis
title_full Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis
title_fullStr Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis
title_full_unstemmed Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis
title_short Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis
title_sort role of macrophage scavenger receptor msr1 in the progression of non-alcoholic steatohepatitis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797536/
https://www.ncbi.nlm.nih.gov/pubmed/36591228
http://dx.doi.org/10.3389/fimmu.2022.1050984
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