Regulation of stem cell fate by HSPGs: implication in hair follicle cycling

Heparan sulfate proteoglycans (HSPGs) are part of proteoglycan family. They are composed of heparan sulfate (HS)-type glycosaminoglycan (GAG) chains covalently linked to a core protein. By interacting with growth factors and/or receptors, they regulate numerous pathways including Wnt, hedgehog (Hh),...

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Autores principales: Colin-Pierre, Charlie, El Baraka, Oussama, Danoux, Louis, Bardey, Vincent, André, Valérie, Ramont, Laurent, Brézillon, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797564/
https://www.ncbi.nlm.nih.gov/pubmed/36577752
http://dx.doi.org/10.1038/s41536-022-00267-y
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author Colin-Pierre, Charlie
El Baraka, Oussama
Danoux, Louis
Bardey, Vincent
André, Valérie
Ramont, Laurent
Brézillon, Stéphane
author_facet Colin-Pierre, Charlie
El Baraka, Oussama
Danoux, Louis
Bardey, Vincent
André, Valérie
Ramont, Laurent
Brézillon, Stéphane
author_sort Colin-Pierre, Charlie
collection PubMed
description Heparan sulfate proteoglycans (HSPGs) are part of proteoglycan family. They are composed of heparan sulfate (HS)-type glycosaminoglycan (GAG) chains covalently linked to a core protein. By interacting with growth factors and/or receptors, they regulate numerous pathways including Wnt, hedgehog (Hh), bone morphogenic protein (BMP) and fibroblast growth factor (FGF) pathways. They act as inhibitor or activator of these pathways to modulate embryonic and adult stem cell fate during organ morphogenesis, regeneration and homeostasis. This review summarizes the knowledge on HSPG structure and classification and explores several signaling pathways regulated by HSPGs in stem cell fate. A specific focus on hair follicle stem cell fate and the possibility to target HSPGs in order to tackle hair loss are discussed in more dermatological and cosmeceutical perspectives.
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spelling pubmed-97975642022-12-30 Regulation of stem cell fate by HSPGs: implication in hair follicle cycling Colin-Pierre, Charlie El Baraka, Oussama Danoux, Louis Bardey, Vincent André, Valérie Ramont, Laurent Brézillon, Stéphane NPJ Regen Med Review Article Heparan sulfate proteoglycans (HSPGs) are part of proteoglycan family. They are composed of heparan sulfate (HS)-type glycosaminoglycan (GAG) chains covalently linked to a core protein. By interacting with growth factors and/or receptors, they regulate numerous pathways including Wnt, hedgehog (Hh), bone morphogenic protein (BMP) and fibroblast growth factor (FGF) pathways. They act as inhibitor or activator of these pathways to modulate embryonic and adult stem cell fate during organ morphogenesis, regeneration and homeostasis. This review summarizes the knowledge on HSPG structure and classification and explores several signaling pathways regulated by HSPGs in stem cell fate. A specific focus on hair follicle stem cell fate and the possibility to target HSPGs in order to tackle hair loss are discussed in more dermatological and cosmeceutical perspectives. Nature Publishing Group UK 2022-12-28 /pmc/articles/PMC9797564/ /pubmed/36577752 http://dx.doi.org/10.1038/s41536-022-00267-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Colin-Pierre, Charlie
El Baraka, Oussama
Danoux, Louis
Bardey, Vincent
André, Valérie
Ramont, Laurent
Brézillon, Stéphane
Regulation of stem cell fate by HSPGs: implication in hair follicle cycling
title Regulation of stem cell fate by HSPGs: implication in hair follicle cycling
title_full Regulation of stem cell fate by HSPGs: implication in hair follicle cycling
title_fullStr Regulation of stem cell fate by HSPGs: implication in hair follicle cycling
title_full_unstemmed Regulation of stem cell fate by HSPGs: implication in hair follicle cycling
title_short Regulation of stem cell fate by HSPGs: implication in hair follicle cycling
title_sort regulation of stem cell fate by hspgs: implication in hair follicle cycling
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797564/
https://www.ncbi.nlm.nih.gov/pubmed/36577752
http://dx.doi.org/10.1038/s41536-022-00267-y
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