Cargando…

Superporous acrylic acid and HPMC hydrogels of mefenamic acid: Formulation, characterization and optimization by central composite design

The purpose of the study was to devise the superporous hydrogels (SPHs) of mefenamic acid (MA) to acquire the sustained action of the MA in the body. The superporous hydrogels of mefenamic acid were formulated by employing the gas blowing method. The central composite rotatable design (CCRD) was app...

Descripción completa

Detalles Bibliográficos
Autores principales: Khan, Hafeez Ullah, Aziz, Samar, Maheen, Safirah, Khan, Ikramullah, Andleeb, Mehwish, Younis, Hina, Haider, Sajjad, Haider, Adnan, Akhtar, Muhammad Saeed, Shafqat, Syed Salman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797584/
https://www.ncbi.nlm.nih.gov/pubmed/36588944
http://dx.doi.org/10.3389/fbioe.2022.1057627
_version_ 1784860713929408512
author Khan, Hafeez Ullah
Aziz, Samar
Maheen, Safirah
Khan, Ikramullah
Andleeb, Mehwish
Younis, Hina
Haider, Sajjad
Haider, Adnan
Akhtar, Muhammad Saeed
Shafqat, Syed Salman
author_facet Khan, Hafeez Ullah
Aziz, Samar
Maheen, Safirah
Khan, Ikramullah
Andleeb, Mehwish
Younis, Hina
Haider, Sajjad
Haider, Adnan
Akhtar, Muhammad Saeed
Shafqat, Syed Salman
author_sort Khan, Hafeez Ullah
collection PubMed
description The purpose of the study was to devise the superporous hydrogels (SPHs) of mefenamic acid (MA) to acquire the sustained action of the MA in the body. The superporous hydrogels of mefenamic acid were formulated by employing the gas blowing method. The central composite rotatable design (CCRD) was applied to optimize the effect of independent formulation factors like acrylic acid (AC), HPMC and glycerol (GLY) over dependent variables like porosity, viscosity, drug content and swelling ratio of superporous hydrogels in water, phosphate buffer (pH 6.8) and in 0.1N HCl (pH 1.2). A number of characteristics such as void fraction, surface morphology by Scanning electron microscopy (SEM) and in vitro drug release study were governed along with physico-chemical analysis by Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC) and appraised statistically by employing the ANOVA. The comparative analgesic activity of optimized superporous hydrogel formulation SPH17 was also analyzed by using tail flick method. The Fourier transform infrared spectroscopy and Differential scanning calorimetry studies approved the physical compatibility between the polymers and the drug. The Scanning electron microscopy study specified micrographic insight about the structure of formed formulations comprising presence of pores, fibers and drug-hole aggregates. The superporous hydrogels were detected to be low dense as they expressed density lower than 0.75 g/cc. The decrease in concentration of the polymers and cross linker contributed towards the increase in the void fraction of the superporous hydrogel formulations. The optimized formulation SPH 17 exhibited a highly sustained release of MA for up to 10 h in the both 0.1 N HCl and phosphate buffer (66.6%) media. The non-fickian release of drug revealed the coupling of the diffusion and polymer relaxation mechanism of the drug release from the formulations. The obtained outcomes suggested that analgesic effect of SPH 17 was significantly (p < 0.05) higher than that of simple suspension of mefenamic acid and total analgesic effect duration for superporous hydrogel was also doubled as compared to the duration of analgesic effect produced by drug suspension. The successfully formulated SPH with HPMC K100M as a gelling agent had sustained the action of the mefenamic acid (MF) by improving its poor solubility and permeability. The introduction of inter-penetrating polymeric network (acrylic acid) using glycerol as a cross linker impart increased residence time to superporous hydrogels which ultimately enhanced the feasibility of using superporous hydrogel as oral sustained release devices particularly for gastric retention.
format Online
Article
Text
id pubmed-9797584
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-97975842022-12-30 Superporous acrylic acid and HPMC hydrogels of mefenamic acid: Formulation, characterization and optimization by central composite design Khan, Hafeez Ullah Aziz, Samar Maheen, Safirah Khan, Ikramullah Andleeb, Mehwish Younis, Hina Haider, Sajjad Haider, Adnan Akhtar, Muhammad Saeed Shafqat, Syed Salman Front Bioeng Biotechnol Bioengineering and Biotechnology The purpose of the study was to devise the superporous hydrogels (SPHs) of mefenamic acid (MA) to acquire the sustained action of the MA in the body. The superporous hydrogels of mefenamic acid were formulated by employing the gas blowing method. The central composite rotatable design (CCRD) was applied to optimize the effect of independent formulation factors like acrylic acid (AC), HPMC and glycerol (GLY) over dependent variables like porosity, viscosity, drug content and swelling ratio of superporous hydrogels in water, phosphate buffer (pH 6.8) and in 0.1N HCl (pH 1.2). A number of characteristics such as void fraction, surface morphology by Scanning electron microscopy (SEM) and in vitro drug release study were governed along with physico-chemical analysis by Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC) and appraised statistically by employing the ANOVA. The comparative analgesic activity of optimized superporous hydrogel formulation SPH17 was also analyzed by using tail flick method. The Fourier transform infrared spectroscopy and Differential scanning calorimetry studies approved the physical compatibility between the polymers and the drug. The Scanning electron microscopy study specified micrographic insight about the structure of formed formulations comprising presence of pores, fibers and drug-hole aggregates. The superporous hydrogels were detected to be low dense as they expressed density lower than 0.75 g/cc. The decrease in concentration of the polymers and cross linker contributed towards the increase in the void fraction of the superporous hydrogel formulations. The optimized formulation SPH 17 exhibited a highly sustained release of MA for up to 10 h in the both 0.1 N HCl and phosphate buffer (66.6%) media. The non-fickian release of drug revealed the coupling of the diffusion and polymer relaxation mechanism of the drug release from the formulations. The obtained outcomes suggested that analgesic effect of SPH 17 was significantly (p < 0.05) higher than that of simple suspension of mefenamic acid and total analgesic effect duration for superporous hydrogel was also doubled as compared to the duration of analgesic effect produced by drug suspension. The successfully formulated SPH with HPMC K100M as a gelling agent had sustained the action of the mefenamic acid (MF) by improving its poor solubility and permeability. The introduction of inter-penetrating polymeric network (acrylic acid) using glycerol as a cross linker impart increased residence time to superporous hydrogels which ultimately enhanced the feasibility of using superporous hydrogel as oral sustained release devices particularly for gastric retention. Frontiers Media S.A. 2022-12-15 /pmc/articles/PMC9797584/ /pubmed/36588944 http://dx.doi.org/10.3389/fbioe.2022.1057627 Text en Copyright © 2022 Khan, Aziz, Maheen, Khan, Andleeb, Younis, Haider, Haider, Akhtar and Shafqat. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Khan, Hafeez Ullah
Aziz, Samar
Maheen, Safirah
Khan, Ikramullah
Andleeb, Mehwish
Younis, Hina
Haider, Sajjad
Haider, Adnan
Akhtar, Muhammad Saeed
Shafqat, Syed Salman
Superporous acrylic acid and HPMC hydrogels of mefenamic acid: Formulation, characterization and optimization by central composite design
title Superporous acrylic acid and HPMC hydrogels of mefenamic acid: Formulation, characterization and optimization by central composite design
title_full Superporous acrylic acid and HPMC hydrogels of mefenamic acid: Formulation, characterization and optimization by central composite design
title_fullStr Superporous acrylic acid and HPMC hydrogels of mefenamic acid: Formulation, characterization and optimization by central composite design
title_full_unstemmed Superporous acrylic acid and HPMC hydrogels of mefenamic acid: Formulation, characterization and optimization by central composite design
title_short Superporous acrylic acid and HPMC hydrogels of mefenamic acid: Formulation, characterization and optimization by central composite design
title_sort superporous acrylic acid and hpmc hydrogels of mefenamic acid: formulation, characterization and optimization by central composite design
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797584/
https://www.ncbi.nlm.nih.gov/pubmed/36588944
http://dx.doi.org/10.3389/fbioe.2022.1057627
work_keys_str_mv AT khanhafeezullah superporousacrylicacidandhpmchydrogelsofmefenamicacidformulationcharacterizationandoptimizationbycentralcompositedesign
AT azizsamar superporousacrylicacidandhpmchydrogelsofmefenamicacidformulationcharacterizationandoptimizationbycentralcompositedesign
AT maheensafirah superporousacrylicacidandhpmchydrogelsofmefenamicacidformulationcharacterizationandoptimizationbycentralcompositedesign
AT khanikramullah superporousacrylicacidandhpmchydrogelsofmefenamicacidformulationcharacterizationandoptimizationbycentralcompositedesign
AT andleebmehwish superporousacrylicacidandhpmchydrogelsofmefenamicacidformulationcharacterizationandoptimizationbycentralcompositedesign
AT younishina superporousacrylicacidandhpmchydrogelsofmefenamicacidformulationcharacterizationandoptimizationbycentralcompositedesign
AT haidersajjad superporousacrylicacidandhpmchydrogelsofmefenamicacidformulationcharacterizationandoptimizationbycentralcompositedesign
AT haideradnan superporousacrylicacidandhpmchydrogelsofmefenamicacidformulationcharacterizationandoptimizationbycentralcompositedesign
AT akhtarmuhammadsaeed superporousacrylicacidandhpmchydrogelsofmefenamicacidformulationcharacterizationandoptimizationbycentralcompositedesign
AT shafqatsyedsalman superporousacrylicacidandhpmchydrogelsofmefenamicacidformulationcharacterizationandoptimizationbycentralcompositedesign