TJ-M2010-5, a novel CNS drug candidate, attenuates acute cerebral ischemia-reperfusion injury through the MyD88/NF-κB and ERK pathway

Background: Cerebral ischemia-reperfusion injury (CIRI) inevitably occurs after vascular recanalization treatment for ischemic stroke. The accompanying inflammatory cascades have a major impact on outcome and regeneration after ischemic stroke. Evidences have demonstrated that TLR/MyD88/NF-κB signal...

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Detalles Bibliográficos
Autores principales: Li, Zeyang, Zhao, Minghui, Zhang, Xiaoqian, Lu, Yiran, Yang, Yang, Xie, Yalong, Zou, Zhimiao, Zhou, Liang, Shang, Runshi, Zhang, Limin, Jiang, Fengchao, Du, Dunfeng, Zhou, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797592/
https://www.ncbi.nlm.nih.gov/pubmed/36588708
http://dx.doi.org/10.3389/fphar.2022.1080438

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