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Associations between paraclinical parameters, symptoms and quality of life in patients with acromegaly: a cross sectional study
INTRODUCTION: Acromegaly is a rare chronic endocrine disorder that can lead to significant quality of life (QoL) impairment and persistent symptomatology in both biochemically uncontrolled as well as in cured or controlled patients. We aimed to conduct an observational cross-sectional study investig...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797626/ https://www.ncbi.nlm.nih.gov/pubmed/36577870 http://dx.doi.org/10.1186/s41687-022-00537-9 |
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author | Gliga, Maximilian Cosma Reti, Zsuzsanna Gliga, Camelia Pascanu, Ionela Maria |
author_facet | Gliga, Maximilian Cosma Reti, Zsuzsanna Gliga, Camelia Pascanu, Ionela Maria |
author_sort | Gliga, Maximilian Cosma |
collection | PubMed |
description | INTRODUCTION: Acromegaly is a rare chronic endocrine disorder that can lead to significant quality of life (QoL) impairment and persistent symptomatology in both biochemically uncontrolled as well as in cured or controlled patients. We aimed to conduct an observational cross-sectional study investigating the associations between biochemical disease control, associated comorbidities, and symptoms severity on QoL in a cohort of acromegalic patients. METHODS: Thirty-one patients with acromegaly were enrolled in our study. AcroQoL and PASQ (Pain assessed acromegaly symptoms questionnaire) questionnaires were applied to all patients. Information about disease status, associated comorbidities, and other relevant clinical and paraclinical data were gathered. RESULTS: Patients with uncontrolled acromegaly presented worse QoL and symptoms scores than controlled patients, but the difference was not statistically significant (AcroQoL 57.22 vs 64.04, p > 0.05; PASQ 12 vs 16.47, p > 0.05). Worse symptoms were significantly associated with impaired QoL (overall symptoms score on PASQ was negatively correlated with AcroQoL total score, r = − 0.61, p < 0.05). Cardiovascular complications were associated with lower QoL scores, but not with worse symptoms (AcroQoL total score in patients with- versus patients without cardiovascular complications: 54.89 vs 70.14, p < 0.05). CONCLUSIONS: Achieving biochemical control of acromegaly might not be enough to reverse the QoL impairment and improve symptomatology in acromegalic patients. While symptoms severity and the presence of cardiovascular complications seem to play an important role in reducing patients QoL, the roles of disease control, diabetes, and pituitary insufficiency are less clear. |
format | Online Article Text |
id | pubmed-9797626 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-97976262022-12-30 Associations between paraclinical parameters, symptoms and quality of life in patients with acromegaly: a cross sectional study Gliga, Maximilian Cosma Reti, Zsuzsanna Gliga, Camelia Pascanu, Ionela Maria J Patient Rep Outcomes Research INTRODUCTION: Acromegaly is a rare chronic endocrine disorder that can lead to significant quality of life (QoL) impairment and persistent symptomatology in both biochemically uncontrolled as well as in cured or controlled patients. We aimed to conduct an observational cross-sectional study investigating the associations between biochemical disease control, associated comorbidities, and symptoms severity on QoL in a cohort of acromegalic patients. METHODS: Thirty-one patients with acromegaly were enrolled in our study. AcroQoL and PASQ (Pain assessed acromegaly symptoms questionnaire) questionnaires were applied to all patients. Information about disease status, associated comorbidities, and other relevant clinical and paraclinical data were gathered. RESULTS: Patients with uncontrolled acromegaly presented worse QoL and symptoms scores than controlled patients, but the difference was not statistically significant (AcroQoL 57.22 vs 64.04, p > 0.05; PASQ 12 vs 16.47, p > 0.05). Worse symptoms were significantly associated with impaired QoL (overall symptoms score on PASQ was negatively correlated with AcroQoL total score, r = − 0.61, p < 0.05). Cardiovascular complications were associated with lower QoL scores, but not with worse symptoms (AcroQoL total score in patients with- versus patients without cardiovascular complications: 54.89 vs 70.14, p < 0.05). CONCLUSIONS: Achieving biochemical control of acromegaly might not be enough to reverse the QoL impairment and improve symptomatology in acromegalic patients. While symptoms severity and the presence of cardiovascular complications seem to play an important role in reducing patients QoL, the roles of disease control, diabetes, and pituitary insufficiency are less clear. Springer International Publishing 2022-12-28 /pmc/articles/PMC9797626/ /pubmed/36577870 http://dx.doi.org/10.1186/s41687-022-00537-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Gliga, Maximilian Cosma Reti, Zsuzsanna Gliga, Camelia Pascanu, Ionela Maria Associations between paraclinical parameters, symptoms and quality of life in patients with acromegaly: a cross sectional study |
title | Associations between paraclinical parameters, symptoms and quality of life in patients with acromegaly: a cross sectional study |
title_full | Associations between paraclinical parameters, symptoms and quality of life in patients with acromegaly: a cross sectional study |
title_fullStr | Associations between paraclinical parameters, symptoms and quality of life in patients with acromegaly: a cross sectional study |
title_full_unstemmed | Associations between paraclinical parameters, symptoms and quality of life in patients with acromegaly: a cross sectional study |
title_short | Associations between paraclinical parameters, symptoms and quality of life in patients with acromegaly: a cross sectional study |
title_sort | associations between paraclinical parameters, symptoms and quality of life in patients with acromegaly: a cross sectional study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797626/ https://www.ncbi.nlm.nih.gov/pubmed/36577870 http://dx.doi.org/10.1186/s41687-022-00537-9 |
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